匹维溴铵片联合双歧杆菌四联活菌片治疗功能性消化不良的疗效及对胃肠激素的影响

Effect of Pinaverium Bromide Tablets Combined with Bifidobacterium Tetravaccine Tablets in the Treatment of Functional Dyspepsia and Its Impact on Gastrointestinal Hormone

目的分析双歧杆菌四联活菌片联合匹维溴铵片治疗功能性消化不良患者的疗效及对其胃肠激素水平的影响。方法选取郑州市金水区总医院2019年9月至2022年9月功能性消化不良患者82例,采用随机抽签法分为单一组、联合组,各41例。单一组采用双歧杆菌四联活菌片治疗,联合组采用双歧杆菌四联活菌片联合匹维溴铵片治疗。比较两组临床疗效,治疗后饮食情况改善率,治疗前后临床症状(腹泻、腹痛),胃肠激素指标[胃动素(MTL)、5-羟色胺(5-HT)、一氧化氮(NO)、胃泌素(GAS)、神经肽Y(NPY)、血管活性肽(VIP)]水平,血液流变学(全血高切黏度、全血低切黏度、血浆黏度)水平及不良反应发生率。结果连续治疗4周后联合组临床总有效率(97.56%)高于单一组(80.49%)(P<0.05);治疗后联合组食欲、进食量及进食时间改善率均大于单一组(P<0.05);治疗后联合组腹泻次数少于单一组,腹痛改善程度大于单一组(P<0.05);治疗后,联合组MTL、NO及NPY水平升高幅度大于单一组,GAS、VIP及5-HT水平降低幅度大于单一组(P<0.05);治疗后联合组全血高切黏度、全血低切黏度及血浆黏度降低幅度均大于单一组(P<0.05);治疗后联合组不良反应发生率(9.76%)与单一组(2.44%)相比,差异无统计学意义(P>0.05)。结论匹维溴铵片联合双歧杆菌四联活菌片治疗功能性消化不良疗效显著,可有效改善临床症状及胃肠激素水平,增强胃动力,促进患者病情恢复。

Objective To investigate the curative effect of bifidobacterium tetravaccine tablets combined with pinaverium bromide tablets in the treatment of functional dyspepsia and its impact on gastrointestinal hormone.Methods A total of 82 patients with functional dyspepsia in Jinshui District General Hospital from September 2019 to September 2022 were selected as research objects and divided into a single group and a combination group with 41 cases in each group according to random drawing method.The single group was treated with bifidobacterium tetravaccine tablets,and the combination group was treated with bifidobacterium tetravaccine tablets combined with pinaverium bromide tablets.Compare the clinical efficacy and improvement rate of dietary status after treatment between the two groups,as well as the clinical symptoms(diarrhea,abdominal pain),levels of gastrointestinal hormone indicators[motilin(MTL),5-serotonin(5-HT),nitric oxide(NO),gastrin(GAS),neuropeptide Y(NPY),vasoactive peptide(VIP)],and levels of hemorheology(whole blood high shear viscosity,whole blood low shear viscosity,and plasma viscosity)before and after treatment,and compare the incidence of adverse reactions between the two groups.Results After treatment,the total effective rate of combination group(97.56%)was higher than that of single group(80.49%),and the difference was statistically significant(P<0.05);the improvement rates of appetite,food intake and eating time in combination group were higher than those in single group after treatment,and the difference was statistically significant(P<0.05);after treatment,the number of diarrhea in the combination group was less than that in the single group,and the improvement of abdominal pain was greater than that in the single group(P<0.05);after treatment,the increase of MTL,NO and NPY levels in combination group was greater than that in single group,and the decrease of GAS,VIP and 5-HT levels was greater than that in single group,with statistical significance(P<0.05);after treatment,the decreases of whole blood high tangential viscosity,whole blood low tangential viscosity and plasma viscosity in combination group were greater than those in single group,and the differences were statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between the combination group(9.76%)and the single group(2.44%)after treatment(P>0.05).Conclusion Pinaverium bromide tablets combined with bifidobacterium tetravaccine tablets is effective in the treatment of functional dyspepsia,which can effectively improve clinical symptoms and gastrointestinal hormone levels,enhance gastric motility,and promote the recovery of the disease.