辅助生殖技术新鲜周期和融胚周期胎儿畸形率情况分析

Analysis of fetal malformation rate in fresh cycle and melt cycle of assisted reproductive technology

目的探讨辅助生殖技术新鲜周期和融胚周期胎儿畸形情况。方法选取进入试管周期移植的35098例不孕症患者,新鲜胚胎移植15049例为对照组,冻融移植20049例为观察组。比较两组胎儿畸形情况及不同类型胎儿畸形情况。结果对照组胎儿畸形88例,畸形率为0.58%;观察组胎儿畸形113例,胎儿畸形率为0.56%。两组胎儿畸形率比较差异无统计学意义(P>0.05)。两组颅脑神经、眼耳面颈、心血管循环、肌肉骨骼、泌尿生殖系统、染色体疾病、消化系统畸形、复杂畸形不同类型胎儿畸形率比较差异无统计学意义(P>0.05)。结论在实施辅助生殖技术期间,胚胎冷冻解冻移植不会增加出生婴儿的畸形率,冷冻解冻胚胎移植技术具有安全性。

Objective To investigate the malformation of infants born in fresh cycle and melt cycle of assisted reproductive technology.Methods35098 infertile patients underwent test-tube cycle transplantation,15049 cases of fresh embryo transplantation were selected as control group,and 20049 cases of freeze-thaw transplantation were selected as observation group.The fetal malformations of two groups and different types of fetal malformations were compared.Results There were 88 cases of fetal malformation in the control group,the malformation rate was 0.58%.In the observation group,there were 113 cases of fetal malformation,the rate of fetal malformation was 0.56%.There was no significant difference in the rate of fetal malformation between the two groups(P>0.05).There was no significant difference in the rates of craniocerebral nerve,eye,ear,facial and neck,cardiovascular circulation,musculoskeletal,genitourinary system,chromosome diseases,digestive system malformations and complex malformations between the two groups(P>0.05).Conclusion During the implementation of assisted reproductive technology,embryo freezing and thawing transfer will not increase the rate of birth defects,and frozen and thawing embryo transfer technology is safe.