血清TREM-1、CRP及HO-1水平与下肢动脉硬化闭塞症介入治疗后血管再狭窄的相关性研究

Correlation between Serum Levels of TREM-1,CRP and HO-1 and Vascular Restenosis after Interventional Therapy in Lower Extremity Arteriosclerosis Obliterans

目的:探讨血清髓系细胞触发受体1(TREM-1)、C反应蛋白(CRP)及血红素氧合酶1(HO-1)水平与下肢动脉硬化闭塞症(LEAOD)介入治疗后血管再狭窄的相关性。方法:回顾性分析2018年1月-2022年2月我院收治的120例LEAOD行介入治疗患者的临床资料,治疗后行1年随访,依据患者复查结果分为再狭窄组(n=40)与未狭窄组(n=80)。比较两组一般资料信息[性别、年龄、体重指数(BMI)、合并疾病(高血压、高脂血症、糖尿病)、住院时间、吸烟史、病变类型(狭窄病变、闭塞病变)、病变部位(左下肢、右下肢、双下肢)]以及实验室指标(TREM-1、CRP、HO-1)表达水平的差异,通过多因素Logistic回归分析明确LEAOD患者介入治疗后再狭窄的危险因素,通过ROC明确年龄、TREM-1、CRP、HO-1预测LEAOD患者介入治疗后再狭窄的价值。结果:两组性别、BMI、住院时间、吸烟史、合并高脂血症、合并糖尿病、病变类型、病变部位比较差异无统计学意义(P>0.05),再狭窄组高血压占比以及年龄、血清TREM-1、CRP、HO-1水平显著高于未狭窄组,差异有统计学意义(P<0.05)。经多因素Logistic回归分析证实,高血压、年龄≥56岁、TREM-1≥310.120ng/L、CRP≥7.535mg/L、HO-1≥13.970μg/L是LEAOD患者介入治疗后再狭窄的危险因素(均P<0.05)。经ROC分析证实年龄、TREM-1、CRP、HO-1均可用于LEAOD患者介入治疗后再狭窄的预测,曲线下面积分别为0.556、0.661、0.779、0.742(均P<0.05)。结论:LEAOD患者介入治疗后再狭窄受到多因素影响,当年龄≥56岁、TREM-1≥310.120ng/L、CRP≥7.535mg/L、HO-1≥13.970μg/L可用于此类患者再狭窄风险的预测。

Objective:To investigate the correlation between the levels of serum myeloid cell trigger receptor 1(TREM-1),C-reactive protein(CRP)and heme oxygenase-1(HO-1)and the restenosis of lower extremity arteriosclerosis obliterans(LEAOD)after interventional therapy.Methods:The clinical data of 120 patients with LEAOD undergoing interventional treatment in our hospital from January 2018 to February 2022 were retrospectively analyzed.After treatment,they were followed up for 1 year.According to the results of patients’reexamination,they were divided into restenosis group(n=40)and non-stenosis group(n=80).To compare the differences in general information\and laboratory indicators(TREM-1,CRP,HO-1)between the two groups,To identify the risk factors for restenosis in LEAOD patients after interventional therapy through multivariate logistic regression analysis,and to determine the value of age,TREM-1,CRP,and HO-1 in predicting restenosis in LEAOD patients after interventional therapy through ROC.Results:There was no significant difference between the two groups in gender,BMI,length of stay,smoking history,hyperlipidemia,diabetes,lesion type,and lesion site(P>0.05).The proportion of hypertension,age,serum TREM-1,CRP,and HO-1 levels in the restenosis group were significantly higher than those in the non-stenosis group(P<0.05).Multiple Logistic regression analysis confirmed that hypertension,age≥56 years old,TREM-1≥310.120ng/L,CRP≥7.535mg/L,and HO-1≥13.970μg/L were risk factors for restenosis in LEAOD patients after interventional treatment(all P<0.05).After ROC analysis,it was confirmed that age,TREM-1,CRP,and HO-1 can all be used to predict restenosis in LEAOD patients after interventional treatment.The area under the curve was 0.556,0.661,0.779,and 0.742,respectively(all P<0.05).Conclusion:The restenosis of LEAOD patients after interventional treatment is influenced by multiple factors.Age≥56 years old,TREM-1≥310.120ng/L,CRP≥7.535mg/L,and HO-1≥13.970μg/L can be used to predict the risk of restenosis in such patients.