白细胞介素-36在肾脏疾病中的作用

Role of interleukin-36 in kidney disease

白细胞介素(interleukin,IL)-36是IL-1家族的重要成员,它是炎症的关键调节器,其促炎激动剂包括IL-36α、IL-36β以及IL-36γ,拮抗剂有IL-36Ra和IL-38,IL-36亚家族成员的共同受体是IL-36受体(IL-36 receptor,IL-36R)。IL-36激动剂和拮抗剂的失衡会导致皮肤疾病、肠道疾病、肺部疾病和肿瘤的发生。近年来有研究发现,IL-36与肾脏疾病的发生发展也密切相关。本文重点综述了IL-36的结构和生物学功能、调控机制及其在肾脏疾病中的作用。

As an important member of IL-1 family,interleukin 36(IL-36)is a key regulator of in-flammation.Its proinflammatory agonists are composed of IL-36α,IL-36βand IL-36γwhile its antago-nists include IL-36Ra and IL-38.And co-receptor of IL-36 subfamily is IL-36 receptor(IL-36R).An im-balance of IL-36 agonists and antagonists may lead to the development of skin diseases,intestinal diseases,lung diseases and tumors.In recent years,many studies have confirmed that IL-36 is correlated closely with the occurrence and development of kidney diseases.This review focused on the structure,biological function,regulatory mechanism and role of IL-36 in kidney disease.