摘要
肾脏疾病是临床上最常见的疾病之一,其进展至终末期肾衰竭将严重危害人类健康,因此对其发病机制的探讨研究以及寻求有效延缓疾病进展的治疗手段意义重大。莫洛尼小鼠白血病病毒前病毒插入位点1(provinal integration site 1 of murine leukemia virus,PIM1)是一种丝氨酸/苏氨酸激酶,具有调控细胞周期、凋亡、免疫、炎症和线粒体完整性等生物学功能。最近研究发现PIM1在肾脏疾病中也具有重要作用,本文围绕PIM1及其在肾脏疾病的发生发展中的作用机制做一综述,为临床肾脏疾病防治提供新的方向。
Kidney disease is one of the most common diseases and end-stage renal failure has se-riously endangered human health.Therefore it is quite imperative to explore its pathogenesis and devise ef-fective measures to delay the progress of kidney diseases.Proviral integration site 1 of murine leukemia virus(PIM1)is a serine/threonine kinase with diverse biological functions of regulating cell cycle,apopto-sis,immune responses,inflammation and mitochondrial integrity.This review focused upon PIM1 and its mechanistic role in the development of kidney disease,providing rationales for a proper management of kidney diseases in clinical practices.
作者
李玉珍
朱杰夫
吴雄飞
Li Yu-zhen;Zhu Jie-fu;Wu Xiong-fei(Department of Nephrology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Organ Transplantation,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《临床肾脏病杂志》
2023年第11期957-961,共5页
Journal Of Clinical Nephrology
基金
国家自然科学基金(82100803)
湖北省自然科学基金(2021CFB101)。
关键词
PIM1激酶
急性肾损伤
糖尿病肾病
狼疮肾炎
癌
肾细胞
PIM1 kinase
Acute kidney injury
Diabetes kidney disease
Lupus nephritis
Carci-noma,Renal cell
