重症急性胰腺炎治疗中超声引导下经皮穿刺置管引流的应用效果

Application Effect of Ultrasound-guided Percutaneous Puncture and Drainage in the Treatment of Severe Acute Pancreatitis

目的探讨重症急性胰腺炎治疗中超声引导下经皮穿刺置管引流(PCD)的应用效果。方法选取2021年1月至2022年12月福建医科大学附属漳州市医院收治的106例重症急性胰腺炎患者展开研究,遵循随机数字表法分组原则,将其分为对照组(常规治疗)与试验组(常规治疗联合PCD治疗),每组53例,观察两组治疗前后各炎性因子[血清降钙索原(PCT)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)]水平变化、临床相关指标(腹痛持续时间、腹胀持续时间、饮食恢复时间、肠鸣音恢复时间、住院时间以及住院费用)、治疗有效率及并发症发生率。结果治疗前,两组患者各炎性因子水平差异无统计学意义,P>0.05;治疗后,两组各炎性因子水平均有所降低,且试验组PCT、CRP、TNF-α以及IL-6水平均低于对照组,P<0.05。试验组腹痛持续时间、腹胀持续时间、饮食恢复时间、肠鸣音恢复时间以及住院时间均短于对照组,且住院费用低于对照组,P<0.05。试验组治疗总有效率90.57%高于对照组的治疗有效率75.47%,P<0.05。试验组并发症发生率11.32%低于对照组的并发症发生率32.08%,P<0.05。结论超声引导下PCD在重症急性胰腺炎中的治疗效果显著,通过清除胰腺炎液、控制炎性反应、提供早期干预以及在操作上的可调节性等优势可有效促进病情的缓解和康复,并提高治疗的成功率。

Objective To explore the application effect of ultrasound-guided percutaneous catheter drainage(PCD)in the treatment of severe acute pancreatitis.Methods This study was conducted on 106 patients with severe acute pancreatitis admitted to our hospital from January 2021 to December 2022.Following the principle of random number table grouping,they were divided into a reference group(conventional treatment)and an experimental group(conventional treatment combined with PCD treatment),with 53 patients in each group.The inflammatory factors(PCT,CRP,TNF-α,IL-6)before and after treatment were observed in both groups,clinical indicators(duration of abdominal pain,duration of bloating,recovery time of diet,recovery time of bowel sounds,hospitalization time,and hospitalization costs),treatment effectiveness rate,and incidence of complications.Results Before treatment,there was no significant difference in the levels of inflammatory factors between the two groups of patients,P>0.05.After treatment,the levels of inflammatory factors in both groups decreased,but in the experimental group,PCT,CRP,TNF-αand IL-6 level was lower than the reference group,P<0.05.The duration of abdominal pain,bloating,dietary recovery,bowel sound recovery,and hospitalization in the experimental group were shorter than those in the control group,and the hospitalization cost was lower(P<0.05).The effective rate of treatment in the experimental group was 90.57%,higher than that in the reference group,which was 75.47%,P<0.05.The incidence rate of complications in the experimental group was 11.32%,lower than the reference group's incidence rate of 32.08%,P<0.05.Conclusions Ultrasound guided PCD has a significant effect in the treatment of severe acute pancreatitis.By clearing pancreatic fluid,controlling inflammatory response,providing early intervention,and adjustable operation,it effectively promotes the remission and recovery of the condition,and increases the success rate of treatment.