摘要
目的探讨血清胸苷激酶1(TK1)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)及dickkopf WNT信号通路抑制剂1(DKK1)对食管癌的诊断价值。方法选取62例食管癌患者作为食管癌组,59例健康体检者作为对照组。对比两组受试者TK1、CYFRA21-1、DKK1水平,对比不同分期食管癌患者TK1、CYFRA21-1、DKK1水平,分析TK1、CYFRA21-1、DKK1单独及联合检测对食管癌的诊断价值。结果食管癌组患者TK1、CYFRA21-1、DKK1水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。Ⅲ~Ⅳ期食管癌患者TK1、CYFRA21-1、DKK1水平均明显高于Ⅰ~Ⅱ期患者,差异均有统计学意义(P﹤0.01)。TK1+CYFRA21-1+DKK1联合检测诊断食管癌的灵敏度和特异度分别为88.50%、79.10%,曲线下面积为0.779(95%CI:0.695~0.864),均高于三者单独检测。结论TK1、CYFRA21-1、DKK1联合检测有利于提高食管癌的诊断效能,防止误诊漏诊,三者对其病情评估具有一定参考价值。
Objective To investigate the diagnostic value of thymidine kinase 1(TK1),cyto-keratin 19 fragment antigen 21-1(CYFRA21-1)and dickkopf WNT signaling pathway inhibitor 1(DKK1)in esophageal cancer.Method A total of 62 patients with esophageal cancer were selected into the esophageal cancer group,and 59 healthy volunteers into the control group.The levels of TK1,CYFRA21-1 and DKK1 in two groups and in esophageal cancer patients with different stages were compared,and the diagnostic value of single and combined detection of TK1,CYFRA21-1 and DKK1 in esophageal cancer were analyzed.Result The levels of TK1,CYFRA21-1 and DKK1 in esophageal cancer group were higher than those in control group(P<0.01);the levels of TK1,CYFRA21-1 and DKK1 in stage Ⅲ-Ⅳ patients were significantly higher than those in stage Ⅰ-Ⅱ(P<0.01).The sensitivity and specificity of TK1+CYFRA21-1+DKK1 detection for the diagnosis of esophageal cancer were 88.50% and 79.10%,respectively,and the area under the curve(AUC)was 0.779(95%CI:0.695-0.864),which were significantly higher than those of the single detection.Conclusion The combined detection of TK1,CYFRA21-1 and DKK1 can improve the diagnostic efficiency of esophageal cancer and prevent misdiagnosis and missed diagnosis,which can provide reference for the disease evaluation of patients.
作者
刘鹏
郝登荣
彭彦才
席俊峰
张志斌
李伟伟
LIU Peng;HAO Dengrong;PENG Yancai;XI Junfeng;ZHANG Zhibin;LI Weiwei(Department of Cardiothoracic Surgery,the First Hospital of Yulin,Yulin 719000,Shaanxi,China)
出处
《癌症进展》
2023年第18期2017-2019,共3页
Oncology Progress
基金
陕西省卫生健康科研基金项目(2022B001)。