艾迪注射液联合顺铂+环磷酰胺化疗对卵巢癌患者癌因性疲乏程度及血常规指标的影响

Effect of Aidi injection combined with cisplatin and cyclophosphamide chemotherapy on the degree of cancer-related fatigue and blood routine indicators in ovarian cancer patients

目的探讨艾迪注射液联合顺铂+环磷酰胺(PC)方案化疗对卵巢癌患者癌因性疲乏程度及血常规指标的影响。方法依据治疗方案的不同将56例卵巢癌患者分为对照组和观察组,每组28例。对照组患者给予PC方案化疗,观察组患者给予艾迪注射液联合PC方案化疗。比较两组患者的癌因性疲乏程度[Piper疲乏修订量表(RPFS)]、血常规指标[白细胞、中性粒细胞、淋巴细胞、血小板、中性粒细胞与淋巴细胞比值(NLR)]、不良反应发生情况。结果治疗后,两组患者RPFS量表各维度评分均低于本组治疗前,观察组患者RPFS量表各维度评分均低于对照组,差异均有统计学意义(P﹤0.05)。治疗后,两组患者白细胞、中性粒细胞、淋巴细胞、血小板均低于本组治疗前,观察组患者NLR高于本组治疗前,对照组患者NLR低于本组治疗前,观察组患者白细胞、中性粒细胞、淋巴细胞、NLR、血小板均高于对照组,差异均有统计学意义(P﹤0.05)。观察组患者的不良反应总发生率为28.57%,与对照组患者的21.43%比较,差异无统计学意义(P﹥0.05)。结论艾迪注射液联合PC方案化疗能减轻卵巢癌患者的癌因性疲乏程度,对血常规指标的影响较小,且不增加不良反应。

Objective To investigate the effect of Aidi injection combined with cisplatin and cyclophosphamide(PC)regimen chemotherapy on the degree of cancer-related fatigue and blood routine indicators in ovarian cancer patients.Method A total of 56 ovarian cancer patients were divided into control group and observation group according to different treatment regimes,with 28 cases in each group.Patients in the control group were given PC regimen chemotherapy,while patients in the observation group were given Aidi injection combined with PC regimen chemotherapy.The degree of cancer-related fatigue[the revised Piper fatigue scale(RPFS)],routine blood indicators[white blood cell,neutrophil,lymphocyte,platelet,and neutrophil-to-lymphocyte ratio(NLR)],and the occurrence of adverse events were compared between the two groups.Result After treatment,the scores of all dimensions of the RPFS scale of the two groups were lower than those before the treatment,the scores of all dimensions of the RPFS scale of the observers were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,the white blood cell,neutrophil,lymphocyte,and platelet of both groups were lower than those before the treatment,the NLR of the observation group was higher than that before the treatment,while the NLR of the control group was lower than that before the treatment,the white blood cell,neutrophil,lymphocyte,NLR and platelet of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).The total incidence rate of adverse events in the observation group was 28.57%,and the difference was not statistically significant compared with 21.43% in the control group(P>0.05).Conclusion Aidi injection combined with PC regimen chemotherapy could reduce cancer-related fatigue in patients with ovarian cancer,has little impact on blood routine level,and does not increase the incidence of toxic and side effects,which is worth popularizing.