“干白沙”方案对急性髓系白血病患者血管内皮生长因子、白细胞介素-6及肿瘤坏死因子-α水平的影响

Effect of IIT regimen on the levels of vascular endothelial growth factor,interleukin-6,and tumor necrosis factor-α in patients with acute myeloid leukemia

目的探讨干扰素α-1b、白细胞介素-2(IL-2)联合沙利度胺(简称“干白沙”)方案对急性髄系白血病(AML)患者血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平的影响。方法将108例AML患者根据治疗方案的不同分为对照组和干白沙组,每组54例。对照组采用柔红霉素+阿糖胞苷(DA)方案治疗,干白沙组采用“干白沙”方案治疗。对比治疗前后两组患者血清VEGF、IL-6、TNF-α水平及外周血T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+))水平,并对比两组患者的临床疗效。结果治疗后,干白沙组患者VEGF、IL-6、TNF-α水平均明显低于对照组,差异均有统计学意义(P<0.01)。治疗后,干白沙组患者CD3^(+)、CD4^(+)水平和CD4^(+)/CD8^(+)均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P<0.05)。干白沙组患者总缓解率高于对照组,差异有统计学意义(P<0.05)。结论对AML患者采用“干白沙”方案治疗,能够有效降低VEGF、IL-6、TNF-α水平,调节机体免疫功能,进一步提升临床疗效。

Objective To investigate the effect of interferonα-1b,interleukin-2(IL-2),and thalidomide(referred to as IIT)regimen on vascular endothelial growth factor(VEGF),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels in patients with acute myeloid leukemia(AML).Method A total of 108 AML patients were divided into control group and IIT group according to different treatment plans,with 54 patients in each group.The control group was treated with the daunorubicin+cytarabine(DA)regimen,and the IIT group was treated with the IIT regimen.The serum VEGF,IL-6,TNF-α levels and peripheral blood T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+))levels were compared between the two groups before and after the treatment.The clinical efficacy of the two groups was also compared.Result After the treatment,the levels of VEGF,IL-6,and TNF-αin the IIT group were significantly lower than those in the control group,and the differences were statistically significant(P<0.01).After the treatment,the CD3^(+),CD4^(+)levels and CD4^(+)/CD8^(+)of the IIT group were higher than those of the control group,while the CD8^(+)level was lower than that of the control group,and the differences were statistically significant(P<0.05).The overall response rate of the IIT group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The IIT regimen for AML patients can effectively reduce the levels of VEGF,IL-6,TNF-α,regulate the patient’s immune function,and further improve the clinical efficacy.