乳腺癌患者3.0T动态增强MRI乳腺背景实质强化程度与其分子亚型及EGFR表达的关系

Relationship between the degree of breast background parenchymal enhancement in 3.0T dynamic enhanced MRI and its molecular subtypes and EGFR expression in patients with breast cancer

目的探究乳腺癌患者3.0T动态增强核磁共振成像(MRI)乳腺背景实质强化(BPE)程度与其分子亚型及表皮生长因子受体(EGFR)表达的关系。方法回顾性分析2020年1月至2022年10月该院收治的乳腺癌患者102例的相关临床资料,收集所有研究对象的3.0T动态增强MRI报告中乳腺BPE程度;根据乳腺BPE程度的不同将上述研究对象分为轻度强化组(40例)、中度强化组(34例)、重度强化组(28例)。采用多因素Logistic回归分析乳腺癌强化程度的影响因素。结果Luminal A型乳腺癌患病率为轻度强化组<中度强化组<重度强化组,Luminal B型乳腺癌患病率为轻度强化组<重度强化组,三阴型乳腺癌患病率为轻度强化组>中度强化组,轻度强化组>重度强化组,Her-2过表达型乳腺癌患病率轻度强化组>重度强化组,差异均有统计学意义(P<0.05)。呈EGFR(-)表达的患病率为轻度强化组<中度强化组<重度强化组,呈EGFR(++)表达的患病率为轻度强化组>重度强化组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,Luminal A型或B型及EGFR阴性表达是乳腺BPE重度强化的危险因素(P<0.05)。结论乳腺癌患者MRI乳腺BPE程度同其分子亚型及EGFR表达存在一定的关联,重度强化提示Luminal A型或B型乳腺癌的概率较高,且EGFR多呈阴性,存在一定的借鉴价值。

Objective To investigate the relationship between the degree of breast background parenchymal enhancement(BPE)with 3.0T dynamic enhanced magnetic resonance imaging(MRI)and the expression of molecular subtypes and epidermal growth factor receptor(EGFR)in patients with breast cancer.Methods A total of 102 cases of breast cancer patients admitted to the hospital from January 2020 to October 2022 were retrospectively analyzed.The degree of BPE of the breast in the 3.0T dynamic contrast-enhanced MRI reports of all subjects was collected.According to the degree of breast BPE,the subjects were divided into mild enhancement group(40 cases),moderate enhancement group(34 cases)and severe enhancement group(28 cases).Multivariate Logistic regression was used to analyze the influencing factors of breast cancer enhancement degree.Results The prevalence of Luminal A breast cancer was mild enhancement group<moderate enhancement group<severe enhancement group,Luminal B breast cancer was mild enhancement group<severe enhancement group,triple negative breast cancer prevalence was mild enhancement group>moderate enhancement group,mild enhancement group>severe enhancement group.The prevalence of Her-2 overexpression breast cancer in mild enhancement group was higher than that in severe enhancement group,and the differences were statistically significant(P<0.05).The prevalence of EGFR(-)expression was mild enhancement group<moderate enhancement group<severe enhancement group,and the prevalence of EGFR(++)expression was mild enhancement group>severe enhancement group,the difference was statistically significant(P<0.05).Multivariate Logistic regression analysis showed that Luminal A or B type and negative expression of EGFR were risk factors for severe enhancement of breast BPE(P<0.05).Conclusion The degree of MRI breast BPE in patients with breast cancer is related to its molecular subtypes and the expression of EGFR.Severe enhancement indicates a high probability of Luminal type A or B breast cancer,and EGFR is often negative,which has certain reference value.