血清总CK、CKMB质量/总CK在心血管疾病中的表达及意义

Expression and significance of serum total CK and CKMB mass/total CK in cardiovascular diseases

目的探讨血清总肌酸激酶(CK)、肌酸激酶同工酶(CKMB)质量/总CK在心血管疾病表达及与患者预后的相关性。方法选择该院2022年1月至2023年1月连续收治的心血管疾病患者225例作为观察组,另选择同期健康体检志愿者100例作为对照组。比较2组血清总CK水平、CKMB质量/总CK,比较不同疾病类型、不同预后心血管疾病患者血清总CK水平、CKMB质量/总CK,应用受试者工作特征(ROC)曲线分析血清总CK水平、CKMB质量/总CK对心血管病预后的诊断价值。结果观察组血清总CK水平、CKMB质量/总CK均高于对照组,差异均有统计学意义(P<0.05)。急性心肌梗死、急性心力衰竭、稳定性心绞痛、不稳定性心绞痛的患者血清总CK水平均高于慢性心力衰竭患者,CKMB质量/总CK均低于慢性心力衰竭患者,差异均有统计学意义(P<0.05)。预后情况为存活的患者总CK水平、CKMB质量/总CK均低于预后情况为死亡的患者,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,总CK诊断心血管病患者预后的曲线下面积(AUC)为0.771,低于CKMB质量/总CK诊断心血管病患者预后的0.824。结论血清总CK水平、CKMB质量/总CK在不同心血管疾病患者中存在明显差异,总CK、CKMB质量/总CK与心血管疾病患者预后密切相关,通过检测上述指标对心血管疾病的分型及患者预后诊断具有一定指导意义。

Objective To investigate the expression of serum total creatine kinase(CK)and creatine kinase isoenzyme(CKMB)mass/total CK in patients with cardiovascular disease and its correlation with prognosis.Methods A total of 225 patients with cardiovascular disease admitted to the hospital from January 2022 to January 2023 were selected as observation group,and 100 healthy volunteers in the same period were selected as control group.The serum total CK level and CKMB mass/total CK were compared between the 2 groups,and the serum total CK level and CKMB mass/total CK were compared between patients with different disease types and different prognosis of cardiovascular diseases.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum total CK level and CKMB mass/total CK for the prognosis of cardiovascular disease.Results The total CK level and CKMB mass/total CK in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).The serum total CK level of patients with acute myocardial infarction,acute heart failure,stable angina pectoris and unstable angina pectoris was higher than that of patients with chronic heart failure,and the CKMB mass/total CK was lower than that of patients with chronic heart failure,and the differences were statistically significant(P<0.05).The total CK level and CKMB mass/total CK in the survival group were lower than those in the death group,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of total CK in the diagnosis of cardiovascular disease was 0.771,which was lower than that of CKMB mass/total CK(0.824).Conclusion The serum total CK level and CKMB mass/total CK are significantly different in patients with different cardiovascular diseases.The total CK and CKMB mass/total CK are closely related to the prognosis of patients with cardiovascular diseases.The detection of the above indicators has certain guiding significance for the classification of cardiovascular diseases and the prognosis diagnosis of patients.