摘要
高毒力肺炎克雷伯菌(hvKP)的致病性强且携带多种毒力基因,常导致严重的社区获得性感染,以及合并眼内炎、败血症等其他部位的迁徙性感染。虽然传统观点认为hvKP对抗菌药物的灵敏度高,但近年来陆续发现了对碳青霉烯类抗菌药物耐药的hvKP(CR-hvKP),高毒力与高耐药的CR-hvKP给临床治疗带来了极大挑战。本文综述了CR-hvKP的流行现状、毒力影响因素及耐药播散机制的研究现状,以期为CR-hvKP的防治提供理论依据。
Hypervirulent Klebsiella pneumoniae(hvKP)is highly pathogenic and carries a variety of virulence genes,which often leads to serious community-acquired infections,and migratory infections associated with endophthalmitis,septicemia and other parts.Although the traditional view holds that hvKP is highly sensitive to antibacterial drugs,carbpenem-resistant hypervirulent Klebsiell a pneumoniae(CR-hvKP)has been found in recent years.CR-hvKP with high virulence and high drug resistance has brought great challenges to clinical treatment.This article reviews the epidemic status,virulence influencing factors,drug resistance and dissemination mechanism of CR-hvKP,in order to provide theoretical basis for the prevention and treatment of CR-hvKP.
作者
孔娜娜
严育忠
杨德平(综述)
刘维薇(审校)
KONG Nana;YAN Yuzhong;YANG Deping;LIU Weiwei(Department of Clinical Laboratory,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Clinical Laboratory,Zhoupu Hospital Affiliated to Shanghai University of Medicine and Health Sciences,Shanghai 201318,China)
出处
《检验医学与临床》
CAS
2023年第23期3531-3536,共6页
Laboratory Medicine and Clinic
基金
上海市浦东新区卫生健康委员会青年科技项目(PW202113-07)。
关键词
肺炎克雷伯菌
高毒力
高黏液表型
碳青霉烯耐药
Klebsiella pneumoniae
hypervirulent
high mucus phenotype
carbapenem-resistance
