缓痛止泻软胶囊治疗腹泻型肠易激综合征的临床疗效及安全性观察

Clinical Efficacy and Safety of Huantong Zhixie Soft Capsules in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome

目的:探讨缓痛止泻软胶囊治疗腹泻型肠易激综合征(IBS-D)的临床疗效。方法:回顾性选取2021年9月至2022年8月该院收治的98例IBS-D患者,按照治疗方式分为观察组及对照组,每组49例。观察组患者使用缓痛止泻软胶囊治疗,对照组患者使用匹维溴铵片治疗,治疗周期均为28 d。比较两组患者治疗前后临床疗效、临床症状、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分以及不良反应发生率。结果:观察组患者的临床有效率为87.76%(43/49),显著高于对照组的63.27%(31/49),差异有统计学意义(P<0.05)。治疗后,两组患者IBS临床症状(腹痛、腹泻和肛门肿胀)评分均显著低于本组治疗前,且观察组患者显著低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者HAMA、HAMD评分均显著低于本组治疗前,观察组患者显著低于对照组,差异均有统计学意义(P<0.05)。观察组、对照组患者不良反应发生率分别为4.08%(2/49)、12.24%(6/49),差异无统计学意义(P>0.05)。结论:缓痛止泻软胶囊治疗IBS-D的疗效显著,能够减轻患者腹痛腹泻、肛门坠胀等临床症状,改善患者的不良情绪,且治疗安全性较高。

OBJECTIVE:To probe into the clinical efficacy of Huantong Zhixie soft capsules in the treatment of diarrhea-predominant irritable bowel syndrome(IBS-D).METHODS:A total of 98 patients with IBS-D admitted into the hospital from Sept.2021 to Aug.2022 were retrospectively analyzed.All patients were divided into the observation group and control group according to the treatment method,with 49 cases in each group.The observation group was treated with Huantong Zhixie soft capsules,while the control group received Pivillium bromide tablets.The treatment cycle was 28 d.The clinical efficacy,clinical symptoms,Hamilton Anxiety Scale(HAMA),Hamilton depression scale(HAMD)before and after treatment and incidence of adverse drug reactions between two groups were compared.RESULTS:The clinical effective rate of observation group was 87.76%(43/49),significantly higher than that of control group 63.27%(31/49),the difference was statistically significant(P<0.05).After treatment,the scores of IBS clinical symptoms(abdominal pain,diarrhea and anal swelling)in two groups were significantly lower than those before treatment,and observation group was significantly lower than the control group,with statistically significant differences(P<0.05).After treatment,the scores of HAMA and HAMD in two groups were significantly lower than those before treatment,and the observation group was significantly lower than the control group,with statistically significant differences(P<0.05).The incidence of adverse drug reactions in the observation group and control group was respectively 4.08%(2/49)and 12.24%(6/49),with no statistically significant difference(P>0.05).CONCLUSIONS:The efficacy of Huantong Zhixie soft capsules in the treatment of IBS-D is significant,which can alleviate clinical symptoms of patients such as abdominal pain,diarrhea and anal swelling,and improve adverse emotions of patients,with higher treatment safety.