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液体活检在妇科恶性肿瘤中的应用进展

Progress in Application of Liquid Biopsy in Malignant Gynecologic Tumor
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摘要 妇科恶性肿瘤主要包括子宫内膜癌、卵巢癌和宫颈癌等,其中卵巢癌和宫颈癌是导致女性癌症死亡的重要原因。妇科恶性肿瘤的早期诊断可提高患者的5年生存率,常见诊断方式为组织活检,但该方式对患者具有一定的危险性。而液体活检对于妇科恶性肿瘤的早期诊断具有重要意义,其较高的灵敏度和特异度有望改变妇科恶性肿瘤的临床诊疗方式。其中,循环肿瘤细胞、循环肿瘤DNA和循环细胞外囊泡等循环肿瘤生物标志物的研究促进了液体活检的快速发展,有望在妇科恶性肿瘤的早期诊断、病情检测、疗效评估、预后判断等领域广泛应用。 Malignant gynecologic tumors mainly include endometrial cancer,ovarian cancer and cervical cancer,among which ovarian cancer and cervical cancer are important causes of cancer death in women.Early diagnosis of malignant gynecologic tumor can improve the 5-year survival rate of the patients.The common diagnostic modality is tissue biopsy,but it is dangerous for the patients.Liquid biopsy is important for the early diagnosis of malignant gynecologic tumor,and its high sensitivity and specificity are expected to change the diagnosis and treatment of malignant gynecologic tumor.Among them,the research on circulating tumor biomarkers such as circulating tumor cells,circulating tumor DNA,and circulating extracellular vesicles has promoted the rapid development of liquid biopsy,which is expected to be widely applied in the early diagnosis,disease detection,efficacy evaluation,prognosis judgment,and other fields of malignant gynecologic tumors.
作者 张鸿 田万家 李怡珂 雷宁静 常蕾 ZHANG Hong;TIAN Wanjia;LI Yike;LEI Ningjing;CHANG Lei(Department of Gynecology and Obstetrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Zhejiang University School of Medicine,Hangzhou 310030,China;Department of Clinical Laboratory,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,China)
出处 《医学综述》 CAS 2023年第21期4511-4517,共7页 Medical Recapitulate
基金 河南省高校创新人才支持计划(21HASTIT044) 中原英才计划(育才系列)(ZYYCYU202012169)。
关键词 妇科恶性肿瘤 液体活检 循环肿瘤细胞 循环肿瘤DNA 循环细胞外囊泡 Malignant gynecologic tumor Liquid biopsy Circulating tumor cells Circulating tumor DNA Circulating extracellular vesicles
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