铁自噬在肝脏疾病中的研究进展

Advances in Study of Ferritinophagy in Liver Diseases

铁自噬是一种以新型选择性自噬方式调节铁代谢的细胞程序,作为铁死亡的重要组成部分,铁自噬可通过核受体共激活因子4介导铁蛋白自噬性降解,促进铁死亡的发生。铁自噬是调控铁死亡的重要靶点,在维持细胞生理性铁稳态、氧化应激、脂质过氧化等病理生理过程中发挥重要作用。由于铁自噬在非酒精性脂肪性肝病、酒精性肝病、肝纤维化等肝脏疾病的发生发展中具有重要作用,未来通过铁自噬调控铁死亡或可成为肝脏疾病治疗的潜在策略。

Ferritinophagy is a cellular program that regulates iron metabolism in a novel selective autophagic manner and is an essential component of ferroptosis.Ferritinophagy can promote ferroptosis through autophagic degradation of ferritin mediated by nuclear receptor coactivator agent 4.Ferritinophagy is an important target for regulating ferroptosis,and plays an important role in maintaining cellular physiological iron homeostasis,oxidative stress,lipid peroxidation,and other pathophysiological processes.Since ferritinophagy has an important role in the development of liver diseases such as non-alcoholic fatty liver disease,alcoholic liver disease,and liver fibrosis,the regulation of ferroptosis through ferritinophagy may be a potential strategy for the treatment of liver diseases in the future.