血清雌二醇及性激素结合蛋白水平对围绝经期妇女肌少症的诊断价值

Diagnostic value of serum estradiol and sex hormone binding protein(SHBG)levels in perimenopausal women with sarcopenia

目的研究血清雌二醇(Estradiol,E2)及性激素结合蛋白(Sex hormone-binding globulin,SHBG)对围绝经期妇女肌少症的诊断价值。方法选择2021年1月1日-2022年12月31日上海市普陀区利群医院收治的122例肌少症患者为肌少症组,选择同期126例健康体检者为非肌少症组。采用酶联免疫吸附法(Enzyme linked immunosorbent assay,ELISA)检测血清中E2、SHBG水平,分析E2、SHBG水平与肌少症发病风险的相关性。根据Logistic回归分析确定围绝经期妇女肌少症发病的危险因素。采用ROC曲线分析血清E2、SHBG水平对围绝经期妇女肌少症诊断的预测价值。结果与非肌少症组相比,肌少症组患者四肢骨骼肌质量指数(Appendicular skeletal muscle,ASMI)、握力、步速、血清E2与SHBG表达水平均降低,差异有统计学意义(P均<0.05),且两组E2与SHBG均呈正相关。Logistic回归分析显示患者年龄、血清E2与SHBG表达水平均为肌少症的发病因素(P<0.05)。随着年龄的增长,肌少症的发病率增长(P<0.05)。ROC曲线分析显示血清E2与SHBG表达水平对围绝经期妇女肌少症的诊断有较好地预测价值。结论血清E2与SHBG水平均为围绝经期妇女肌少症的发病因素,对肌少症有较好的诊断价值。

Objective Study the diagnostic value of serum estradiol(E2)and sex hormone binding protein(SHBG)in perimenopausal women with sarcopenia.Methods 122 patients with sarcopenia admitted to the hospital from January 1,2021 to December 31,2022 were selected as the sarcopenia group,while 126 healthy individuals in the same period were selected as the non sarcopenia group.Enzyme linked immunosorbent assay(ELISA)was used to detect the levels of E2 and SHBG in serum,and the correlation between E2 and SHBG levels and the risk of sarcopenia was analyzed.Determine the risk factors for the onset of sarcopenia in perimenopausal women based on logistic regression analysis.ROC curve was used to analyze the predictive value of serum E2 and SHBG levels in the diagnosis of sarcopenia in perimenopausal women.Results Compared with the non sarcopenia group,the sarcopenia group had lower levels of limb skeletal muscle mass index(ASMI),grip strength,gait speed,serum E2 and SHBG expression,with statistically significant differences(P<0.05),and both groups had a positive correlation between E2 and SHBG.Logistic regression analysis showed that the patient age,serum E2 and SHBG expression levels were all factors contributing to sarcopenia(P<0.05).The incidence rate of myopenia was increased with age(P<0.05).ROC curve analysis showed that serum E2 and SHBG expression levels had good predictive value for the diagnosis of sarcopenia in perimenopausal women.Conclusion Serum E2 and SHBG levels are both pathogenic factors for sarcopenia in perimenopausal women and have good diagnostic value for sarcopenia.