人类微生物群和胰腺癌关系的研究进展

RESEARCH PROGRESS ON CONNECTING THE HUMAN MICROBIOME AND PANCREATIC CANCER

胰腺癌是一种恶性程度极高的消化道肿瘤,在世界范围内发病率不断上升。胰腺癌的发病可能与吸烟、饮酒和糖尿病有一定的相关性,目前仍没有特别明确的与胰腺癌发病相关的致病因素。最近,研究者将人类微生物群与胰腺癌的发生发展联系起来,紊乱的微生物群可以改变正常细胞的内环境,如改变细胞信号传导通路,增强肿瘤细胞的免疫逃避和入侵,从而促进与癌症相关过程的发生。在本文中,我们将重点介绍一些与胰腺癌和微生物群有关的前沿研究,并探索微生物群对胰腺癌发生发展的作用从而为胰腺癌病因的探索方向和加强这一研究领域的方法提供一个新的思路。

Pancreatic cancer is a deadly disease that is increasing in incidence throughout the world.The incidence of pancreatic cancer may be related to smoking,drinking and diabetes.At present,there is no specific pathogenic factor related to pancreatic cancer.Recently,a few studies have linked the human microbiome to pancreatic cancer development.A per-turbed microbiome has been shown to alter normal cells while promoting cancer-related processes such as increased cell sig-naling,immune system evasion and invasion.In this article,we will review in detail the alterations within the gut and oral mi-crobiome that have been linked to pancreatic cancer and explore the ability of other microbiomes,such as the lung and skin microbiome,to contribute to disease development.Understanding ways to identify a perturbed microbiome can result in ad-vancements in pancreatic cancer research and allow for prevention,earlier detection and alternative treatment strategies for patients.