月苄三甲氯铵和过硫酸钾复合盐对犬瘟热病毒和犬细小病毒消毒效果的比较

Comparison of Disinfection Effects of Benzyl Trimethylammonium Chloride and Potassium Persulfate Compound Salt on CDVand CPV

消毒剂可以切断病原传播途径,清除或杀灭动物体表以及环境中的病原微生物,抑制其繁殖,从而达到控制动物传染病传播的目的。为了解月苄三甲氯铵和过硫酸钾复合盐消毒剂对犬类病毒(RNA病毒和DNA病毒)的灭活效果,选择犬瘟热病毒(canine distemper virus,CDV)和犬细小病毒(canine parvovirus,CPV)开展消毒效果评估。分别把这两种类型消毒剂与CDV、CPV体外发生作用后感染细胞,通过观察细胞病变来判断其与消毒剂作用后的感染能力。结果显示:月苄三甲氯铵和过硫酸钾复合盐消毒剂对于CDV和CPV的消毒效果有一定差异,两种类型消毒剂与CDV作用24h均能将其全部杀灭,但均未能将CPV彻底灭活,其中过硫酸钾复合盐对CDV和CPV的灭活效果较好。结果表明:这两种消毒剂对犬类病毒均有一定的灭活效果,在临床中均有一定的应用价值,但在临床应用时应适当延长与消毒剂的作用时间,定期更换消毒剂,同时要考虑其安全性和外界环境因素影响。本研究为临床犬病毒性疾病防控中消毒剂的选择提供了参考。

Disinfectants could control the spread of animal infectious diseases through cutting off the transmission pathways of viruses,and removing or killing pathogenic microorganisms on the surface of animals and in environment to inhibit their reproduction.In order to investigate the inactivation effect of the compound disinfectant of trimethylammonium chloride and potassium persulfate on canine viruses(RNA and DNA viruses),canine distemper virus(CDV)and canine parvovirus(CPV)were selected for evaluation on the disinfection effects.The two disinfectants were used to respectively react with CDV and CPV in vitro to infect cells,then the virus infection capacity was evaluated through observing the cytopathic effect.The results showed that the disinfection effect of the two disinfectants on CDV and CPV was different to some extent;the two disinfectants could effectively kill all CDV after 24 hours,but fail for CPV,and the inactivation effect of potassium persulfate composite salt on CDV and CPV was better.In conclusion,the two disinfectants could inactivate canine viruses to some extent,with certain application value in clinical practice,but the action time with disinfectants should be extended appropriately,and the disinfectants should be replaced regularly,meanwhile,their safety and external environmental factors should also be taken into consideration.A reference was thus provided for the selection of disinfectants in future prevention and control of clinical canineviral diseases.