CT脑灌注成像定量分析在急性脑梗死患者早期诊断中的应用研究

Application of CT cerebral perfusion imaging quantitative analysis in early diagnosis of patients with acute cere⁃bral infarction

目的 探讨CT脑灌注成像定量分析在急性脑梗死患者早期诊断中的应用效果。方法 选择急性脑梗死患者122例为对象并进行回顾性分析,所有患者均行脑CT检查并进行CT定量分析,观察梗死部位、大小情况并对定量分析结果进行比较。结果 缺血半暗带(IP)区血容量(CBV)与健侧区比较,差异无统计学意义(t=1.92,P>0.05),而平均通过时间(MTT)、达峰时间(TTP)值明显延长,脑血流量(CBF)值明显降低,差异均有统计学意义(t分别=12.76、11.13、-28.22,P均<0.05);IP区与脑梗区比较,CBV、CBF值明显升高,MTT值延长,TTP缩短,差异均有统计学意义(t分别=29.29、17.20、16.86、-23.79,P均<0.05);IP区相对脑血流量(rCBF)、相对平均通过时间(rMTT)、相对达峰时间(r TTP)、相对血容量(rCBV)与脑梗区比较,差异均有统计学意义(t分别=11.32、12.82、12.17、6.66,P均<0.05)。结论 CT脑灌注成像定量分析能够准确反映急性脑梗死患者脑血流灌注情况,通过区分患者脑组织灌注IP区、健侧区与脑梗区,对急性脑梗死患者早期诊断病变部位、范围与有无IP区提供可靠的影像学依据。

Objective To investigate the application effect of CT cerebral perfusion imaging quantitative analysis in the early diagnosis of patients with acute cerebral infarction.Methods A total of 122 patients with acute cerebral infarc-tion were selected as the subjects and analyzed retrospectively.All patients underwent brain CT examination and quantita-tive analysis of CT,the location and size of the infarct and compared the quantitative analysis results were observed.Re-sults There was no significant difference in cerebral blood volume(CBV)between the ischemic penumbra(IP)area and the healthy side area(t=1.92,P>0.05),while the mean transit time(MTT)and time to peak(TTP)values were significantly prolonged,and the cerebral blood flow(CBF)values were significantly decreased(t=12.76,11.13,-28.22,P<0.05).Compared with the cerebral infarction area,the CBV and CBF values in the IP area were significantly increased,the MTT value was prolonged,and the TTP was shortened,differences were statistically significant(t=29.29、17.20、-16.86、23.79,P<0.05).The rCBF,rMTT,rTTP and rCBV between IP area and cerebral infarction area were significant-ly different(t=11.32,12.82,12.17,6.66,P<0.05).Conclusion Quantitative analysis of CT cerebral perfusion imaging can accurately reflecting the cerebral blood perfusion in patients with acute cerebral infarction,by distinguishing the pa-tient's brain tissue perfusion IP area,the healthy side area and the cerebral infarction area,to providing a reliable imag-ing basis for the early diagnosis of the lesion location,extent and the presence or absence of IP area in patients with acute cerebral infarction.