中药自组装纳米策略在肿瘤治疗中应用的研究进展

Application of Self-assembled Nano-strategies of Traditional Chinese Medicine in Tumor Therapy:A Review

中药自组装纳米策略(CSAN)是利用中药成分的自组装特性,使中药成分通过非共价键力自组装形成结构稳定的纳米制剂,中药自组装纳米制剂的形成往往是多种非共价键力的协同结果,很多中药单体因为结构的特殊性容易发生自组装,中药自组装现象在中药单药或复方的水煎液中也普遍存在。研究发现CSAN能够提高中药活性成分的溶解度和生物利用度,对难溶性中药成分的开发和应用具有积极意义,中药汤剂中的自组装现象与疗效之间具有密切关系,研究中药自组装现象为解释中药汤剂起效机制带来新的视角。将CSAN应用于肿瘤领域既可以直接发挥中药活性成分的抗肿瘤作用,又可以作为天然纳米载体包载化疗药物进行联合化疗,提高药物的靶向性,增强抗肿瘤疗效,并降低化疗不良反应,具有优秀的应用潜力。中药自组装纳米制剂制备方法简单易行,成本低廉,具有比传统纳米制剂更好的安全性,有利于推动纳米制剂的临床转化,也有助于为推动中药现代化进程提供新的策略和视角。该文基于近年来在该领域的研究,通过检索中国知识基础设施工程(CNKI)、PubMed、万方、维普等数据库,对中药自组装纳米粒的形成机制、不同组装形式、形成条件和稳定性进行了概述,并总结了CSAN在不同肿瘤治疗中的应用,为进一步研究CSAN提供参考依据。

Chinese medicine self-assembly nano-strategies(CSAN)is to utilize the self-assembly property of Chinese medicine components,so that the Chinese medicine components can self-assemble to form structurally stable nano-preparations through non-covalent interactions.The formation of Chinese medicine selfassembly nano-preparations is often a synergistic result of a variety of non-covalent interactions,and many Chinese medicine monomers are susceptible to self-assembly due to their structural characteristics,and the phenomenon of self-assembly of Chinese medicine is also common in the decoction of single or compound Chinese medicine,which has attracted the attention of researchers.It is found that CSAN can improve the solubility and bioavailability of active components in Chinese medicine,which is of positive significance for the development and application of insoluble components of Chinese medicine.The self-assembly phenomenon of Chinese medicine decoction is closely related to the therapeutic efficacy,and the study of self-assembly phenomenon of Chinese medicine will bring a new perspective for the explanation of the mechanism of Chinese medicine decoction.At the same time,traditional Chinese medicine(TCM)has unique advantages in the field of anti-tumor.The application of CSAN in the field of oncology can not only exert the anti-tumor effect of the active components of Chinese medicine directly,but also act as a natural nano-carrier to carry chemotherapy drugs for combination chemotherapy,improve the targeting of drugs,enhance the anti-tumor efficacy,and reduce the side effects of chemotherapy,which has excellent anti-tumor potential.The preparation method of Chinese medicine self-assembly nano-preparations is simple,low cost,and has better safety than traditional nano-preparations,which is conducive to the promotion of the clinical transformation of nano-preparations,and also helps to provide new strategies and perspectives for promoting the modernization of TCM.Therefore,based on a large number of researches in this field in recent years,this paper reviewed the formation mechanism,different assembly forms,formation conditions and stability of Chinese medicine self-assembly nano-preparations by searching databases such as China national knowledge infrastructure(CNKI),PubMed,WanFang data and VIP,and summarized the application of CSAN in different tumor therapies,providing a reference for further research on CSAN.