淀粉样脑血管病相关脑出血患者血肿增大的影响因素

Influencing factors of hematoma enlargement in patients with cerebral amyloid angiopathy-related intracerebral hemorrhage

目的分析淀粉样脑血管病(CAA)相关脑出血患者住院期间血肿增大的影响因素。方法分析2016年7月—2023年7月江南大学附属医院收治于神经外科、神经内科、急诊科符合CAA纳入标准的患者242例,将其分为血肿增大组48例和血肿无增大组194例,对影响血肿增大的因素进行Logistic分析。结果Logistic分析显示高龄(OR:1.064,95%CI:1.018-1.113,P=0.006)、高收缩压(OR:1.063,95%CI:1.015-1.113,P=0.009)、使用三七类药物(OR:5.078,95%CI:2.191-11.766,P<0.001)、高血钙水平(OR:0.033,95%CI:0.005-0.202,P=0.033)是CAA相关脑出血患者住院期间血肿增大的影响因素。结论CAA相关脑出血患者血肿增大的影响因素中高龄、高收缩压、使用三七类药物为危险因素,高血钙水平为保护因素。

Objective To analyze and summarize the factors affecting hematoma enlargement in patients with cerebral amyloid angiopathy-related intracerebral hemorrhage during hospitalization,and to provide guidance for reducing its incidence.Methods The data of 242 patients admitted to neurosurgery,neurology,and emergency department who met the inclusion criteria from July 2016 to July 2023 were retrospectively analyzed.They were divided into hematoma enlargement group(n=48)and non-hematoma enlargement group(n=194).A statistical analysis was performed for influencing factors.Results Multivariate logistic analysis showed that advanced age(OR:1.064,95%CI:1.018-1.113,P=0.006),high systolic blood pressure(OR:1.063,95%CI:1.015-1.113,P=0.009),Panax notoginseng drugs(OR:5.078,95%CI:2.191-11.766,P<0.001),high blood calcium(OR:0.033,95%CI:0.005-0.202,P=0.033)difference was statistically significant.Conclusion Advanced age,high systolic blood pressure,Panax notoginseng drugs and high blood calcium were the influencing factors of hematoma enlargement in patients with cerebral amyloid angiopathy-related cerebral hemorrhage.Advanced age,high systolic blood pressure and Panax notoginseng drugs were risk factors,high blood calcium was protective factor.