标准内科治疗联合丁苯酞干预不同区域脑梗死疗效差异性分析

Comparison of effectiveness of standard medical treatment combined with butylphthalide administration for cerebral infarction in different regions

目的通过回顾脑梗死患者治疗前后的美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分变化,评估标准内科治疗联合丁苯酞干预下脑梗死位置与疗效的关系。方法对2019年2月至2021年6月在云南省曲靖市第二人民医院接受住院治疗的207例前循环脑梗死患者进行回顾性研究。接受标准内科治疗联合丁苯酞的患者为观察组(127例),仅接受标准内科治疗的患者为对照组(80例)。依据脑梗死位置分为皮质区梗死和皮质下梗死。观察2组患者治疗前后的NIHSS评分结果,并比较治疗后2组患者不同位置脑梗死的预后情况。结果2组患者治疗前后NIHSS评分差值比较,差异有统计学意义(P=0.011)。2组患者皮质区梗死治疗前后NIHSS评分差值比较,差异有统计学意义(P=0.004);2组患者皮质下梗死治疗前后NIHSS评分差值比较,差异无统计学意义(P=0.625)。结论标准内科治疗联合丁苯酞可更好地改善皮质区梗死功能。

Objective To retrospectively evaluate the relationship between infarct location and the effectiveness of standard medical treatment combined with butylphthalide administration through analyzing the change in National Institutes of Health Stroke Scale(NIHSS)score before and after treatment in patients with ischemic stroke.Methods A retrospective study was conducted on 207 patients with anterior circulation infarction who were hospitalized in the Qujing Second People's Hospital of Yunnan Province from February 2019 to June 2021.They received either standard medical treatment combined with butylphthalide administration(observation group,127 cases)or standard medical treatment alone(control group,80 cases).The NIHSS score before and after treatment was compared between the two groups,and a subgroup analysis was further performed for the prognosis of patients with cortical infarction and those with subcortical infarction.Results There was a significant difference in the change in NIHSS score before and after treatment between the two groups(P=0.011).The difference in NIHSS score before and after treatment was significantly different between the two groups of patients with cortical infarction(P=0.004),but not between the two groups of patients with subcortical infarction(P=0.625).Conclusions Standard medical treatment combined with butylphthalide administration can better improve the function of patients with cortical infarction.