前庭神经鞘瘤的研究进展

Research advances in vestibular schwannoma

前庭神经鞘瘤是一种临床上较为常见的疾病,随着听力学筛查方案和神经影像学的发展,其诊出率有了很大提高,不少肿瘤在较小时即发现,有些甚至在无症状体检时发现。治疗方法已经发展到在切除肿瘤的同时应保留面神经功能并尽可能保留患侧有效听力。肿瘤直径>3 cm应首选显微手术治疗,对于较小肿瘤者,尽管治疗选择可包括观察性影像学随访、放射治疗和显微手术治疗等,但主流观点认为尽早手术仍为首选。此外,随着对疾病发病机制的不断研究,未来生物靶向治疗可能是一种新兴的治疗选择。

Vestibular schwannoma(VS)is a relatively common disease in clinical practice,and with the development of audiology screening regimens and neuroimaging,the detection rate of VS has been greatly improved.Many tumors are found in the early stage,and some are even found in physical examination when there are no symptoms.The development of treatment methods has achieved tumor resection while preserving facial nerve function and effective hearing of the affected side as much as possible.Microsurgery is the preferred treatment method for tumors with a diameter of>3 cm,and as for small and medium-sized tumors,although treatment options include observational imaging follow-up,radiotherapy,and microsurgery,surgery should be performed as early as possible.In addition,with in-depth research on the pathogenesis of the disease,biological targeted therapy may be an emerging treatment option in the future.