慢性硬膜下血肿患者术后康复期间应用辛伐他汀的效果观察

Observation on the Effect of Simvastatin in Patients with Chronic Subdural Hematoma During Postoperative Rehabilitation

目的:探讨钻孔引流术慢性硬膜下血肿患者应用辛伐他汀的效果,并分析对其血清NSE、TNF-α水平及复发的影响。方法:选择2022年1月—12月医院收治的60例慢性硬膜下血肿患者作为研究对象,经随机数字表法分为对照组(n=30)与观察组(n=30),对照组给予钻孔引流术,观察组在对照组基础上加用辛伐他汀治疗。比较两组残余血肿量、神经功能[美国国立卫生研究院卒中量表(NIHSS)评分、血清神经元特异性烯醇化酶(NSE)]、炎症因子水平[血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]以及术后血肿复发情况。结果:两组患者治疗1周、治疗1个月、治疗2个月残余血肿量少于治疗前,且观察组少于对照组(P<0.05);两组患者NIHSS评分、血清NSE低于治疗前,且观察组低于对照组(P<0.05);两组患者血清TNF-α、IL-6低于治疗前,且观察组低于对照组(P<0.05);观察组患者血肿复发率低于对照组(P<0.05)。结论:钻孔引流术后应用辛伐他汀可以改善慢性硬膜下血肿患者血清NSE、TNF-α水平,降低术后血肿复发风险。

Objective:To investigate the effect of simvastatin on serum NSE,TNF-αlevels and recurrence in patients with chronic subdural hematoma after drilling and drainage.Method:A total of 60 patients with chronic subdural hematoma admitted to the hospital from January to December 2022 were selected as the research objects.They were divided into control group(n=30)and observation group(n=30)by random number table method.The control group was given drilling and drainage,and the observation group was treated with simvastatin on the basis of the control group.The residual hematoma volume,neurological function[National Institutes of Health Stroke Scale(NIHSS)score,serum neuron-specific enolase(NSE)],inflammatory factor levels[serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]and postoperative hematoma recurrence were compared between the two groups.Results:The amount of residual hematoma in the two groups after 1 week,1 month and 2 months of treatment was less than that before treatment,and that in the observation group was less than that in the control group(P<0.05).The NIHSS score and serum NSE of the two groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).The serum levels of TNF-αand IL-6 in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).The recurrence rate of hematoma in the observation group was lower than that in the control group (P<0.05). Conclusion: The application of simvastatin after drilling and drainage can improve the levels of serum NSE and TNF-α in patients with chronic subdural hematoma and reduce the risk of postoperative hematoma recurrence.