绒毛膜促性腺激素联合达英-35治疗多囊卵巢综合征的效果

Effect of Chorionic Gonadotropin Combined with Diane-35 in the Treatment of Polycystic Ovary Syndrome

目的:探讨绒毛膜促性腺激素联合达英-35治疗多囊卵巢综合征的疗效。方法:选取2019年2月—2022年2月我院妇科诊治的多囊卵巢综合征患者110例作为研究对象,随机分为联合组55例与参照组55例。参照组给予达英-35治疗,联合组在参照组治疗基础上给予绒毛膜促性腺激素治疗,比较两组治疗效果、不良反应、血清指标[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、抗米勒管激素(anti-Müllerian hormone,AMH)、黄体生成素(Luteinizing hormone,LH)、睾酮(testosterone,T)]。结果:治疗6个周期后,联合组治疗总有效率高于参照组(P<0.05);联合组不良反应发生率与参照组比较,差异无统计学意义(P>0.05);联合组TNF-α、AMH、LH、T水平低于参照组(P<0.05)。结论:绒毛膜促性腺激素联合达英-35治疗多囊卵巢综合征的效果确切,可抑制血清TNF-α、AMH的释放,降低血清LH与T水平,且不增加不良反应发生概率。

Objective:To explore and analysis the therapeutic effect of chorionic gonadotropin combined with diane-35 in the treatment of polycystic ovary syndrome.Methods:A total of 110 patients with polycystic ovary syndrome diagnosed and treated in gynecology department of our hospital from February 2019 to February 2022 were selected as the research objects,and they were randomly divided into combined group(55 patients)and reference group(55 patients).The control group was treated with Diane-35,and the combined group was treated with chorionic gonadotropin on the basis of the control group.The therapeutic effect,adverse reactions and serum indexes[tumor necrosis factor-α(TNF-α),anti-Müllerian hormone(AMH),Luteinizing hormone(LH),testosterone(T)]were compared between the two groups.Results:After 6 cycles of treatment,the total effective rate of treatment in the combined group was higher than that in the reference group(P<0.05).There was no significant difference in the incidence of adverse reactions between the combined group and the reference group(P>0.05).The levels of TNF-α,AMH,LH and T in the combined group were lower than those in the reference group(P<0.05).Conclusion:Chorionic gonadotropin combined with Diane-35 is effective in the treatment of polycystic ovary syndrome,which can inhibit the release of serum TNF-αand AMH,reduce serum LH and T levels,and does not increase the incidence of adverse reactions.