胆汁酸代谢异常在非酒精性脂肪性肝病发展中的作用

Role of Abnormal Bile Acid Metabolism in the Development of Non-alcoholic Fatty Liver Disease

非酒精性脂肪性肝病逐渐成为全球儿童发病率最高的慢性肝病之一,肠肝循环中扮演重要角色的胆汁酸在其发病机制中的作用日渐突出。近年来,研究发现胆汁酸是法尼醇X受体和G蛋白偶联受体5的信号分子,二者作为胆汁酸受体调控全身代谢。胆汁酸代谢失衡与NAFLD严重程度密切相关。对胆汁酸及其受体在NAFLD进展中的作用进行综述,以期为NAFLD无创诊断及治疗提供新的靶点。

Non-alcoholic fatty liver disease is emerging as one of the most prevalent chronic liver diseases in children worldwide,and bile acids,which play an important role in the enterohepatic circulation are becoming increasingly prominent in its pathogenesis.In recent years,it has been found that bile acids are[1]signaling molecules for farnesol X receptor and G protein-coupled receptor 5,both of which act as bile acid receptors to regulate systemic metabolism.The imbalance of bile acid metabolism is closely related to the severity of NAFLD.This article reviews the role of bile acids and their receptors in the progression of NAFLD with the aim of providing new targets for the noninvasive diagnosis and treatment of NAFLD.