脓毒症的免疫监测和免疫治疗

Immune monitoring and immunotherapy of sepsis

脓毒症是由宿主对感染反应失调引起的危及生命的器官功能障碍,是ICU最常见的死亡原因之一。过去的动物实验和临床研究表明,脓毒症不仅会引起过度炎症,还会同时导致免疫系统功能障碍和抗菌免疫力受损,而免疫治疗是增强宿主感染抵抗力的最根本方法。本文重点阐述脓毒症免疫应答的主要机制、免疫监测手段以及逆转免疫功能障碍的新型免疫治疗潜在制剂,为脓毒症的免疫治疗提供参考。

Sepsis refers to life-threatening organ dysfunction caused by a dysregulated host response to infection,and has become one of the most common causes of death in intensive care units.Previous animal experiments and clinical studies have shown that sepsis not only causes excessive inflammation,but also leads to immune system dysfunction and impaired antimicrobial immunity.Therefore,immunotherapy is a fundamental approach to enhance host resistance to infection.The main mechanisms of immune response,the approaches of immune monitoring,and the potential immunotherapies for sepsis,attempting to provide some insights for immune monitoring and immunotherapy of sepsis are summarized in this article.