粪菌移植治疗肝性脑病的研究进展

Research progress on fecal microbiota transplantation for hepatic encephalopathy

肝性脑病是肝硬化或肝衰竭患者常见并发症和导致死亡的主要原因,药物治疗后仍会反复发作。人类肠道菌群种类多、数量大,与机体免疫和肠道的正常生理功能密切相关。近年来,有很多粪菌移植治疗多种肠道和肠道外疾病,如复发性艰难梭菌感染、炎症性肠病、非酒精性脂肪肝和肝硬化等。本文就粪菌移植治疗肝硬化或肝衰竭并发肝性脑病的研究进展进行总结,旨在为肝性脑病的治疗提供参考。

Hepatic encephalopathy is a common complication and the main cause of death in patients with liver cirrhosis or liver failure,and it often recurrences after medication.Human intestinal microbiota comprises diverse species and has large quantity,which is closely related to the immune system and the normal physiological function of intestinal tract.In recent years,there have been many reports of fecal microbiota transplantation in the treatment of various intestinal and extraintestinal diseases,such as recurrent Clostridium difficile infection,inflammatory bowel disease,non-alcoholic fatty liver disease,cirrhosis and other diseases.The clinical research progresses of fecal microbiota transplantation in the treatment of liver cirrhosis or liver failure complicated with hepatic encephalopathy are reviewed in this article,so as to provide reference for the treatment of hepatic encephalopathy.