富马酸丙酚替诺福韦对乙型肝炎病毒母婴阻断的作用

Research progress of tenofovir alafenamide fumarate for preventing mother-to-child transmission of hepatitis B virus

母婴传播是HBV传播的主要途径之一,减少围产期传播是一个全球性的问题。富马酸丙酚替诺福韦(TAF)和富马酸替诺福韦酯(TDF)是目前公认的治疗乙型肝炎的主要抗病毒药物,TDF已被证明在降低孕妇血清HBV DNA水平和预防母婴传播发病率方面是有效和相对安全,而TAF在预防母婴传播方面的有效性和安全性数据相对较少,本文就国内外有关妊娠期应用TAF的情况作一概述。

Mother-to-child transmission is one of the primary ways of HBV transmission,and reducing mother-to-child transmission is a global issue.Tenofovir alafenamide fumarate(TAF)and tenofovir disoproxil fumarate(TDF)are widely recognized as the main antiviral drugs for the treatment of hepatitis B.TDF has been shown to be effective and relatively safe in reducing serum HBV-DNA levels in pregnant women and preventing the incidence of mother-to-child transmission.However,there is limited data on the effectiveness and safety of TAF in preventing mother-to-child transmission.In this review,a brief overview of the domestic and international use of TAF during pregnancy is summarized.