光生物调节作用对颅颌面骨修复的影响

Effects of Photobiomodulation on Craniomaxillofacial Bone Repair

目前颅颌面骨缺损相关疾病面临修复速率较慢、骨再生能力有限等问题,常导致缺损区域愈合延迟甚至不愈合,严重影响患者生活质量,寻找更为高效的颅颌面骨修复策略已成为该领域重点研究方向。光生物调节作用是指利用不同光源引发对机体的光物理和光化学调节作用,具有非侵入性、操作简单、时空精度高等优点,为加速颅颌面骨修复提供一种有前景的方式。本文系统总结光生物调节作用调控颅颌面骨修复的有效参数,阐述光生物调节作用对颅颌面骨修复的作用机制,并对目前光生物调节装置在临床的转化应用进行总结展望,为实现高效、安全的颅颌面骨修复策略提供参考。

Craniomaxillofacial bone defects are with problems such as slow repair rate and limited bone regeneration ability,which often lead to delayed or even non-healing of the defect area,seriously affecting the quality of life of patients.Finding more efficient craniomaxillofacial bone repair strategies has become a key research direction in the field.Photobiomodulation refers to the method of using different light sources to produce beneficial therapeutic effects,which has the advantages of non-invasive,simple operation and high spatial and temporal accuracy,and provides a promising way to accelerate cranio-maxillofacial bone repair.In this review,we systematically summarized the effective parameters of photobiomodulation on craniomaxillofacial bone repair,elaborated the mechanisms of photobiomodulation on craniomaxillofacial bone repair,and summarized the prospects of the current clinical transformation application of photobiomodulation devices,so as to provide reference for realizing efficient and safe craniomaxillofacial bone repair strategies.