血清CTRP9水平与胰岛素抵抗及肥胖的关系

Association of serum CTRP9 levels with insulin resistance and obesity

目的探讨血清补体C1q肿瘤坏死因子相关蛋白(CTRP)9水平与胰岛素抵抗及肥胖的关系。方法选取2020年9月至2022年9月在该院就诊的患者为研究对象,其中新诊断的2型糖尿病(nT2DM)患者102例(nT2DM组)、糖耐量受损(IGT)患者98例(IGT组),选择同期于该院体检的体检健康者92例作为糖耐量正常(NGT)组。采用双抗体夹心法测定血清CTRP9和脂联素水平。采用Pearson相关和多因素Logistic回归分析血清CTRP9水平与胰岛素抵抗及肥胖的关系。结果IGT组和nT2DM组血清CTRP9水平均高于NGT组,血清脂联素水平均低于NGT组(P<0.05)。超重和肥胖者血清CTRP9水平明显高于正常体重者(P<0.05)。血清CTRP9水平与体重指数、空腹血糖、空腹胰岛素、糖化血红蛋白、胰岛素抵抗指数和低密度脂蛋白胆固醇呈正相关(P<0.05),与高密度脂蛋白胆固醇和脂联素呈负相关(P<0.05)。血清CTRP9水平为T2DM发生的独立危险因素(OR=1.835,95%CI 1.227~1.843,P<0.05)。结论血清CTRP9水平与胰岛素抵抗密切相关,提示CTRP9可能在2型糖尿病的发生发展中起重要作用。

Objective To investigate the relationship between serum C1q tumor necrosis factor-related protein(CTRP)9 level and insulin resistance and obesity.Methods Patients who were treated in the hospital from September 2020 to September 2022 were selected as the research objects,including 102 patients with newly diagnosed type 2 diabetes mellitus(nT2DM)were selected as nT2DM group and 98 patients with impaired glucose tolerance(IGT group).A total of 92 healthy people who underwent physical examination in the same hospital during the same period were selected as the normal glucose tolerance(NGT)group.Serum CTRP9 and adiponectin levels were measured by double-antibody sandwich assay.Pearson correlation and multivariate Logistic regression analysis were used to analyze the relationship between serum CTRP9 level and insulin resistance or obesity.Results The serum CTRP9 levels in IGT group and nT2DM group were higher than those in NGT group,and the serum adiponectin levels were lower than those in NGT group(P<0.05).Serum CTRP9 levels were significantly higher in overweight and obese subjects than in normal weight subjects(P<0.05).Serum CTRP9 level was positively correlated with body mass index,fasting plasma glucose,fasting insulin,glycated hemoglobin A1c,insulin resistance and low density lipoprotein cholesterol(P<0.05),and negatively correlated with high density lipoprotein cholesterol and adiponectin(P<0.05).Serum CTRP9 level was an independent risk factor for T2DM(OR=1.835,95%CI 1.227-1.843,P<0.05).Conclusion Serum CTRP9 level is closely related to insulin resistance,suggesting that CTRP9 may play an important role in the development of type 2 diabetes mellitus.