基于NO相关信号通路探讨针刺抗抑郁的研究现状

Research Status of Acupuncture in Treating Depression Based on NO-Related Signaling Pathways

一氧化氮(NO)是中枢神经系统重要的信使分子,参与了包括抑郁症在内的许多神经系统疾病的病理生理;目前由NO相关通路介导的抑郁症的病理机制仍不清晰,且研究的信号通路多单一,容易导致多通路、多机制之间的交互联系被忽略。针刺作为传统治疗方法,可多层次、多靶点治疗抑郁症,亦发挥了中医整体观念,达到“调神”的目的。鉴于此,笔者整理国内外相关文献,以揭示抑郁症的潜在病理机制,为针刺治疗抑郁症的研究提供新的思路。

Nitric oxide(NO)is an important messenger molecule in the central nervous system and is involved in the pathophysiology of many neurological disorders,for example depression.Currently,the pathological mechanisms of depression mediated by NO-related pathways are still unclear,and most of the studied signaling pathways are single,which easily leads to the neglect of the interactive links between multiple pathways and mechanisms.As a traditional treatment method,acupuncture can be used to treat depression at multiple levels and targets,and it also plays the holistic concept of Chinese medicine to achieve the purpose of‘regulating Shen’.In view of this,the author collected the relevant literature at home and abroad and revealed the underlying pathological mechanisms of depression and provided new ideas for the study of acupuncture treatment for depression.