接受生物制剂治疗克罗恩病患者的营养风险与临床内镜特征分析

Correlation Between Nutritional Risk and Clinical and Endoscopic Features in Crohn's Disease Patients Treated With Biological Agents

背景:近年广泛应用的生物制剂可改善部分克罗恩病(CD)患者的营养状况,改变疾病进程。目的:探讨接受生物制剂治疗CD患者的营养风险与临床内镜特征的关系。方法:选取2021年6月—2022年6月安徽医科大学第一附属医院收治的68例接受生物制剂治疗的CD患者,采用营养风险筛查2002(NRS2002)进行营养风险筛查,并分析其与临床内镜特征的关系。结果:在68例接受生物制剂治疗的CD患者中,营养风险发生率为66.2%。不同疾病行为、SES⁃CD评分、术后Rutgeerts评分的CD患者的营养风险发生率相比差异均有统计学意义(P均<0.05),而营养风险与患者年龄、病变部位、肛周病变、CDAI评分、确诊CD距生物制剂使用的时间间隔等均无明显相关性(P均>0.05)。结论:接受生物制剂治疗的CD患者的营养风险发生率较高,且营养风险与CD疾病行为、SES⁃CD评分、术后Rutgeerts评分存在关联。

Background:The widespread use of biological agents in recent years can improve the nutritional status of partial patients with Crohn's disease(CD)and change the course of the disease.Aims:To investigate the correlation between the nutritional risk and clinical and endoscopic features in CD patients treated with biological agents.Methods:Sixty⁃eight CD patients treated with biological agents from June 2021 to June 2022 at the First Affiliated Hospital of Anhui Medical University were enrolled.Nutritional risk screening was conducted by nutritional risk screening 2002(NRS2002),and its correlation with clinical and endoscopic features was analyzed.Results:In 68 CD patients treated with biological agents,incidence of nutritional risk was 66.2%.There was statistically significant difference in incidence of nutritional risk in patients with different disease behaviors,SES⁃CD score and postoperative Rutgeerts score(all P<0.05).The incidence of nutritional risk was not correlated with age,lesion location,perianal lesion,CDAI score,and the interval between CD diagnosis and the use of biological agents(all P>0.05).Conclusions:The incidence of nutritional risk is high in CD patients treated with biological agents,and is correlated with CD disease behavior,SES⁃CD score,and postoperative Rutgeerts score.