钛种植体表面Ag/HA涂层的制备及其生物活性

Synthesis of Ag-doped Hydroxyapatite Coating on Titanium Dental Implant Surfaces Evaluation of Biological Activity

采用水热法制备不同含量银掺杂纳米羟基磷灰石[Ca_(10)(PO_(4))_(6)(OH)_(2)∶Ag]粉体,使用傅里叶变换红外光谱(FTIR)、透射电镜(TEM)、X射线衍射(XRD)对粉体进行表征,在口腔用钛种植体表面电泳沉积银掺杂纳米羟基磷灰石陶瓷,扫描电子显微镜(SEM)对银掺杂纳米羟基磷灰石陶瓷进行表征,体外细胞培养测试陶瓷的生物活性。结果表明,当电泳悬浮液中Ag^(+)含量为15%(质量百分比)时,制备的(Ag/HA)粉体呈棒状,长度在100~250 nm之间,直径在20 nm。小鼠骨骼肌细胞在Ag-HA涂层改性后的钛种植体表面能够有效粘附生长,表现出良好的生物活性。

In this study for the synthesis of silver-doped hydroxyapatite[Ca_(10)(PO_4)_6(OH)_(2) ∶Ag] by a hydrothermal method,X-ray diffffraction(XRD),FTIR and transmission electron microscopy(TEM).Furthermore,the Ca_(10)(PO_4)_6(OH)_(2) ∶Ag ceramic coating on Ti for dental implant applications,the surface properties of the ceramics were characterized by scanning electron microscopy(SEM).In addition,the cell adhesion,proliferation of the Ca_(10)(PO_4)_6(OH)_(2) ∶Ag ceramics were also evaluated.Results revealed that the synthesized nanoparticles are hexagonal crystalline Ca_(10-x)Ag_(2x)(PO_4)_6(OH)_2(Ag/HA),Ag/HA exhibits mesoporous nanorods like nanoparticles with 20 nm width and 100~250 nm length,with less agglomeration in the amount of Ag 15wt% condition.The cell study clearly reveals that the Ag/HA ceramic with possible application in medicine.