单磷酸腺苷活化蛋白激酶通过调控能量代谢对肿瘤发挥双重作用的研究进展

Advances in the dual role of adenosine 5'-monophosphate-activated protein kinase on tumors by regulating energy metabolism

目的探讨单磷酸腺苷活化蛋白激酶(AMPK)通过调控能量代谢对肿瘤发挥双重作用的机制,为靶向AMPK治疗肿瘤提供理论基础。方法应用PubMed及中国知网数据库检索系统,以“adenosine 5’-monophosphate-activated protein kinase(AMPK)、tumor、metabolic regulator、Metformin”为英文关键词,以“单磷酸腺苷酸活化蛋白激酶、肿瘤、能量代谢、二甲双胍”为中文关键词,交叉检索2002年1月-2023年4月的相关文献。纳入标准:(1)AMPK的结构及调控能量代谢的作用;(2)AMPK通路在肿瘤中的调控作用;(3)AMPK在肿瘤治疗中的临床应用。排除标准:与肿瘤相关性较小及质量较低的文章。最终纳入文献61篇。结果AMPK在不同肿瘤类型、分期以及治疗方式中,通过调控糖代谢、脂代谢和蛋白质代谢等,发挥抑癌或促癌的双重作用。结论AMPK可以通过调控肿瘤代谢微环境发挥其促癌或抑癌作用,具有潜在的肿瘤临床治疗价值,但其作用于肿瘤的复杂机制仍需进一步探索。

Objective To investigate the mechanism of the dual role of adenosine 5'-monophosphate-activated protein kinase(AMPK)in tumors by regulating energy metabolism,and to provide a theoretical basis for targeting AMPK in cancer therapy.Methods Using PubMed database and China National Knowledge Infrastructure(CNKI)retrievalsystem.The relevant literature from January 2002to April 2023was searched with the keywords“AMP-activated protein kinase,tumor,metabolic regulator,Metformin”.The relevant literature was rationally analyzed and summarized according to the inclusion criteria:(1)the structure and energy metabolism functions of AMPK;(2)the regulatory role of AMPK pathway in cancer;(3)the clinical applications of AMPK in cancer therapy,and the exclusion criteria:literature less relevant to tumors and those in poor quality.According to the inclusion and exclusion criteria,61literature was included.Results AMPK plays a dual role in inhibiting or promoting cancer by regulating glucose,lipid,and protein metabolism in different tumor types,stages,and treatment methods.Conclusion AMPK can exert its cancer-promoting or cancer-suppressing effects by regulating the tumor metabolic microenvironment,which has potential clinical therapeutic value for tumors,but the complex mechanism of its action on tumors still needs to be further explored.