桃红四物汤加减方联合弹力绷带对植皮术后供皮区增生性疤痕的疗效观察

Observation on the Curative Effect of Taohong Siwu Decoction Combined with Elastic Bandage on Hypertrophic Scars in Donor Area After Skin Grafting

【目的】观察桃红四物汤加减方联合弹力绷带对植皮术后供皮区增生性疤痕气滞血瘀型患者的临床疗效。【方法】将62例植皮术后供皮区增生性疤痕气滞血瘀型患者随机分为观察组和对照组,每组各31例。对照组给予采用弹力绷带加压包扎的常规治疗,观察组在对照组常规治疗的基础上给予口服桃红四物汤加减方治疗,疗程为9周。观察2组患者治疗前后疤痕外观温哥华瘢痕量表(VSS)评分以及疤痕瘙痒和疼痛程度的变化情况,并评价2组患者的临床疗效及安全性。【结果】(1)治疗9周后,观察组的总有效率为93.55%(29/31),对照组为70.97%(22/31),组间比较(χ^(2)检验),观察组的临床疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的疤痕外观VSS评分、疤痕瘙痒及疼痛程度均较治疗前明显降低(P<0.05),且观察组的降低作用均明显优于对照组,差异均有统计学意义(P<0.05)。(3)治疗过程中,2组患者均无明显不良反应发生。【结论】桃红四物汤加减方联合弹力绷带加压包扎对植皮术后供皮区增生性疤痕具有较好的改善疗效,其疗效优于单纯弹力绷带加压疗法,且安全性良好。

Objective To observe the clinical efficacy of Taohong Siwu Decoction combined with elastic bandage on patients with hypertrophic scars in the skin donor area after skin grafting of qi stagnation and blood stasis type.Methods Sixty-two patients with hypertrophic scars in the skin donor area after skin grafting were randomly divided into an observation group and a control group,with 31 patients in each group.The control group was given the conventional treatment of compression with elastic bandage,and the observation group was given oral use of modified Taohong Siwu Decoction on the basis of the conventional treatment for the control group.Both groups of patients were treated for 9 weeks.The changes of scar appearance Vancouver Scar Scale(VSS)scores as well as the degree of scar itching and pain in the two groups before and after treatment were observed,and the clinical efficacy and safety of the two groups of patients were also evaluated.Results(1)After 9 weeks of treatment,the total effective rate of the observation group was 93.55%(29/31)and that of the control group was 70.97%(22/31).The intergroup comparison(tested by chi-square test)showed that the clinical efficacy of the observation group was significantly superior to that of the control group,and the difference was statistically significant(P<0.05).(2)After treatment,the scar appearance VSS score,scar itching and pain degree of patients in the two groups were significantly reduced compared with those before treatment(P<0.05),and the lowering effect in the observation group was significantly superior to that of the control group,the differences being statistically significant(P<0.05).(3)During the treatment process,no obvious adverse reactions occurred in both groups.Conclusion The combination of modified Taohong Siwu Decoction and elastic bandage exerts superior efficacy in improving hypertrophic scars in the skin donor area after skin grafting,and its efficacy is superior to that of compression with elastic bandage alone,with good safety profile.