基于微流控技术的药物分析新进展

Recent advances in microfluidics-based pharmaceutical analysis

微流控是指通过微纳加工技术将微通道或微腔室整合到几平方厘米的芯片上并用于模拟各种功能和特征。其核心理念是通过构建微纳器件将复杂的实验室功能集成到单个芯片上。近年来,微流控技术在医药相关学科,尤其是药物分析学领域显示了广阔的发展前景。微流控技术有望成为一种变革新药研发路径和精准医疗模式的“颠覆性技术”。本综述总结了基于微流控技术的药物分析研究新进展。首先归纳了不同类型的微流控芯片及基于微流控的药物分离和分析技术;之后评述了用于药物分析的各种微流控芯片仿生模型,主要总结了基于微流控芯片的三维器官结构仿生模型和器官微生理环境模型;接着评述了近年来微流控芯片在药物成分与药物效应分析中的应用研究新进展;最后讨论了微流控芯片在药物分析研究领域的挑战与机遇。

Microfluidics refers to the integration of microchannels or microchambers into a chip of a few square centimeters through micro-nanofabrication techniques,which can simulate various functions and features.The core concept is to integrate complex laboratory functions into a single analytical device or chip by building micro-and nano-devices.Microfluidics has a promising future in pharmaceutical-related disciplines,especially in the field of pharmaceutical analysis.Microfluidics is expected to become a"disruptive technology"that will change the path of new drug development and precision medicine.This review summarizes the advances in microfluidic-based drug analysis.First,different types of microfluidic chips,microfluidics-based separation and analysis technologies of pharmaceuticals are summarized.Then,various microfluidic chip bionic models for drug analysis,mainly microfluidic-based microphysiological systems and 3D biomimetic organoid models are discussed.Following,the research progress of microfluidics in drug analysis is also reviewed.Finally,the challenges and opportunities of microfluidics in pharmaceutical analysis are outlooked.