中央记忆型T细胞与肿瘤免疫治疗的相关性研究进展

Research progress on the relationship between central memory T cells and tumor immunotherapy

记忆T细胞(memory T cell,Tm)作为人体免疫系统中的一个组成部分,在免疫应答中发挥着至关重要的作用。中央记忆型T细胞(central memory T cell,Tcm)是幼稚T细胞经过抗原激活后,产生的具有长期记忆性的、并能够归巢到淋巴结接受抗原再刺激的T细胞。肿瘤免疫治疗的抗肿瘤作用及不良反应的发生与T细胞功能密切相关,Tcm不仅是介导免疫应答的防线,其作为疗效预测生物标记物的研究也取得了相当大的进展。目前肠道菌群对肿瘤免疫治疗的影响备受关注,肠道菌群及其代谢产物通过影响肿瘤微环境调控疗效,其在免疫细胞层面的机制值得探究。本文对Tcm在组织中的分化、表面标记,在肿瘤免疫治疗中的作用及其与肠道菌群的联系等方面的研究进展进行综述。

Memory T cells(Tm),a component of the human immune system,play a crucial role in immune response.Central memory T cells(Tcms)are produced by naïve T cells after antigen activation and exhibit long-term memory,facilitating homing to lymph nodes for antigen re-stimulation.The efficacy of tumor immunotherapy and the occurrence and treatment of adverse events are closely related to T cell function.Tcms not only serve as a defense line in mediating immune responses but also hold promise as predictive biomarkers of efficacy.Currently,the impact of intestinal flora on tumor immunotherapy has attracted considerable attention.The flora itself and its metabolites modulate the efficacy of immune response by influencing the tumor microenvironment(TME),requiring in-depth investigation into the immune cell mechanisms.This review summarizes research progress on the functions of Tcm on tissue differentiation,surface markers,roles of Tcms in tumor immunotherapy,and the association between the intestinal flora and Tcms.