中药重金属生物可给性与生物有效性研究进展

Research progress on bio-accessibility and bioavailability of heavy metals in traditional Chinese medicine

中药作为我国传统医学的重要组成部分,在国内外深受关注。近年来,由中药重金属累积所致的人体健康风险为其推广、使用带来了一定的阻碍。重金属累积产生的人体健康风险不仅取决于其总量,与其生物可给性和生物有效性更是密切相关。因此,研究中药重金属生物可给性及生物有效性具有重要的科学意义和应用价值。本文综述了中药重金属污染现状与形势,阐述了中药重金属生物可给性与生物有效性的研究概况,以中药原药的生长环境、自身性质、加工过程及测定条件等方面为切入点,深入分析影响中药及其制品重金属生物可给性与生物有效性的关键因素,以期为中药重金属污染风险防控提供理论依据和技术支持。

As an important part of traditional medicine in our country,traditional Chinese medicine has attracted much attention both at home and abroad.However,in recent years,the human health risks caused by the accumulation of heavy metals in traditional Chinese medicine have brought some obstacles to its popularization and application.The health risks caused by heavy metals accumulation depend not only on their total amount,but also on their bio-accessibility and bioavailability.Therefore,it is of great scientific significance and application value to study the bio-accessibility and bioavailability of heavy metals in Chinese traditional medicine.In this paper,the present situation of heavy metal pollution in traditional Chinese medicine was reviewed,and the research progress on the bio-accessibility and bioavailability of heavy metals in traditional Chinese medicine was described.The key factors affecting the bio-accessibility and bioavailability of heavy metals in traditional Chinese medicine and its products were analyzed in depth,starting from the growth environment,self-properties,processing process and testing conditions of original Chinese medicine.We hope to be able to provide theoretical basis and technical support for the prevention and control of heavy metal pollution risks of traditional Chinese medicine.