小剂量秋水仙碱对心绞痛合并急性高尿酸血症患者血尿酸血管紧张素Ⅱ与C反应蛋白的改善作用

Improvement effect of low-dose colchicine on blood uric acid,angiotensinⅡ,and C-reactive protein in the treatment of angina pectoris combined with acute hyperuricemia

目的探究心绞痛合并急性高尿酸血症患者采用小剂量秋水仙碱治疗的效果,及其血尿酸、血管紧张素Ⅱ与C反应蛋白水平的变化情况,以期为临床治疗心绞痛合并急性高尿酸血症提供参考依据。方法选取河南省濮阳市中医医院2021年6月至2023年2月收治的心绞痛合并急性高尿酸血症患者82例作为此研究对象,按照随机数字表法将82例患者分为参照组(41例)与观察组(41例)。参照组采用大剂量的秋水仙碱口服治疗,观察组采用小剂量的秋水仙碱口服治疗,治疗周期为1周。比较2组临床效果,治疗前及治疗3、7 d后数字疼痛评分量表(NRS)评分,治疗前后血尿酸、血管紧张素Ⅱ、红细胞沉降率、炎症因子指标水平,以及治疗期间头痛、恶心呕吐、肝功能异常、腹泻发生情况。结果观察组经过临床治疗1周后临床有效率为95%,高于参照组的83%,差异无统计学意义(P>0.05);相较于治疗前,2组治疗3、7 d后NRS评分及治疗后血尿酸、血管紧张素Ⅱ、红细胞沉降率均降低(P<0.05),但经比较,治疗后2组患者上述指标差异无统计学意义(P>0.05);相较于治疗前,2组经过临床治疗后发现C反应蛋白、白细胞介素-1、白细胞介素-6水平降低,观察组低于参照组;相较于参照组,观察组头痛、恶心呕吐、肝功能异常、腹泻总发生率降低(P<0.05)。结论不同剂量秋水仙碱治疗心绞痛合并急性高尿酸血症患者所达到的临床效果相当,均可达到减轻患者疼痛症状的效果,其中小剂量秋水仙碱治疗对减轻炎症损伤更明显,还可降低不良反应,安全性良好。

Objective To investigate the effect of low-dose colchicine treatment on patients with angina pectoris combined with acute hyperuricemia,as well as the changes in blood uric acid,angiotensinⅡ,and C-reactive protein levels,in order to provide reference basis for clinical treatment of angina pectoris combined with acute hyperuricemia.Methods Eighty-two patients with angina pectoris combined with acute hyperuricemia admitted to Puyang Traditional Chinese Medicine Hospital from June 2021 to February 2023 were selected as the study subjects.According to method of randomized numerical table,82 patients were divided into the reference group(41 cases)and the observation group(41 cases).The reference group was treated with high-dose colchicine orally,while the observation group was treated with low-dose colchicine orally,with a treatment period of 1 week.The clinical effects of the two groups,including the scores of the Digital Pain Scale(NRS)before and after treatment for 3 and 7 days,as well as the levels of blood uric acid,angiotensinⅡ,red blood cell sedimentation rate,inflammatory factor indicators before and after treatment,as well as the occurrence of headache,nausea and vomiting,liver dysfunction,and abdominal diarrhea during the treatment period,were compared.Results The clinical effective rate of the observation group after one week of clinical treatment was 95%,which was higher than that of the reference group,which was 83%,and there was no statistically significant difference(P>0.05);Compared with the pre-treatment period,the NRS score,blood uric acid,angiotensinⅡ,and erythrocyte sedimentation rate in both groups decreased after 3 and 7 days of treatment(P<0.05).However,after comparison,there was no statistically significant difference between the above indexes of the two groups of patients(P>0.05);Compared to before treatment,after clinical treatment,it was found that the levels of C-reactive protein,interleukin-1,and interleukin-6 in the two groups decreased,and the observation group was lower than the reference group;Compared to the control group,the total incidence of headache,nausea and vomiting,liver dysfunction,and diarrhea in the observation group decreased(P<0.05).Conclusion The clinical effects of different doses of colchicine in treating patients with angina pectoris combined with acute hyperuricemia are equivalent,and all of them can achieve the effect of alleviating pain symptoms in patients.Among them,low-dose colchicine treatment is more effective in reducing inflammatory damage and reducing adverse reactions,and It can also reduce adverse reactions,with good safety.