温郁金化学成分、药理作用、临床应用的研究进展及其质量标志物的预测分析

Research progress in chemical constituents,pharmacological effects,and clinical application of Curcuma wenyujin and prediction of its quality markers

温郁金作为传统中药材“浙八味”之一,为浙江省道地药材,应用广泛,具有消淤散结、行气活血和清心解郁等功效。现代研究表明其具有抗肿瘤、抗炎、抗氧化、抗血栓和保肝等药理作用,主要含有倍半萜类、单萜类、二萜类和姜黄素类等多种化学成分。该文对温郁金近十年来化学成分和药理作用的研究进展进行综述,结合传统功效探讨现代临床应用,并以质量标志物(quality marker,Q-marker)概念为理论依据,从植物亲缘、药性、药效、炮制和化学成分可测性等方面对其质量标志物进行预测分析,为未来建立更科学的质量评价体系及其进一步研究应用提供参考。

Curcuma wenyujin,as one of the eight Daodi-herbs in Zhejiang province,is widely used.It has the effects of eliminating stasis and dissipating mass,moving Qi and activating blood,and clearing heart and relieving depression.Modern studies have shown that it has anti-tumor,anti-inflammatory,anti-oxidation,anti-thrombus and liver-protecting effects and mainly contains sesquiterpenoids,monoterpenoids,diterpenoids,and curcumins.This paper reviews the research progress in the chemical constituents and pharmacological effects of C.wenyujin in the last decade,discusses the modern clinical applications combined with the traditional efficacy,and predicts its quality markers(Q-markers) from plant consanguinity,medicinal properties,efficacy,processing and measurability of chemical components based on the theory of Q-markers,so as to provide a reference for the establishment of a scientific quality evaluation system and the research and application of this herb in the future.