蛋白质精氨酸甲基转移酶在血液肿瘤疾病中的作用研究进展

Progress on the role of PRMTs in hematological malignancy diseases

蛋白质精氨酸甲基转移酶(protein arginine methyltransferases,PRMTs)家族具有广泛的分子功能,在干细胞发育系统中参与造血细胞的发生、发育、增殖和分化。在血液肿瘤疾病中,PRMTs可通过甲基化途径参与许多重要的生物学过程,包括细胞增殖、细胞周期控制、基因转录、DNA损伤修复。PRMTs的异常表达可导致肿瘤的发生与发展,特别是在儿童白血病中,通过靶向PRMTs治疗,降低PRMTs的表达,可以有效地抑制肿瘤细胞的增殖和存活。因此,PRMTs与血液肿瘤疾病的关系备受关注,未来很可能成为治疗的一个重要靶标。该文对PRMTs在血液肿瘤疾病中的作用及其机制作一综述,以期为血液肿瘤疾病的治疗提供新的思路。

The protein arginine methyltransferases(PRMTs)family has a wide range of molecular functions and is involved in the generation,development,proliferation and differentiation of hematopoietic cells in the stem cell development.In hematological malignancy diseases,PRMTs can be involved in many important biological processes including cell proliferation,cell cycle,gene transcription,and DNA damage repair through methylation pathways.The abnormal expression of PRMTs can lead to the occurrence and development of malignancy diseases,especially in childhood leukemia.Targeted PRMTs therapy can effectively inhibit the proliferation and survival of tumor cells by reducing the expression of PRMTs.Therefore,the relationship between PRMTs and hematological malignancy diseases has received much attention and is likely to become an important target for treatment in the future.This article reviews the role and mechanism of PRMTs in hematological malignancy diseases,in order to provide new strategies for the treatment of hematological malignancy diseases.