变应原免疫治疗的作用机制及临床应用进展

Progress on mechanisms and clinical application of allergen immunotherapy

变应原免疫治疗(allergen immunotherapy,AIT)是一种治疗过敏性疾病的有效治疗方法,其应用已有1个多世纪。目前AIT主要有两种给药方式:皮下注射免疫治疗(subcutaneous immunotherapy,SCIT)和舌下含服免疫治疗(sublingual immunotherapy,SLIT),其目的是诱导患者对变应原的免疫耐受,给患者带来长期的临床益处。AIT的有效性已有大量的循证医学证据证实,对其作用机制的研究也不断深入,AIT联合生物制剂等在临床已有较为广泛的应用。

Allergen immunotherapy(AIT)is an effective treatment for allergic diseases that have been used for more than a century.At present,AIT is administered in two main ways:subcutaneous immunotherapy(SCIT)and sublingual immunotherapy(SLIT),which aims to induce immune tolerance to allergens and provide long-term clinical benefit to patients.The effectiveness of AIT has been confirmed and the research on its mechanism has been deepened,and AIT combined with biological agents has been widely used in clinical practice.