NF-κB在幽门螺杆菌诱导胃癌发展及治疗中的作用研究进展

Research progress on the role of NF-κB in the development and treatment of H.pylori-induced gastric cancer

胃癌(gastric cancer,GC)是全球发病率第五位的肿瘤,2020年世界范围内胃癌死亡人数为768793人,占总癌症死亡人数的7.7%。我国是胃癌的高发病率国家,总体生存率低,治疗预后差,对人民身体健康和国家经济发展造成重大影响。人类病原体幽门螺杆菌(Helicobacter pylori,H.pylori)感染是导致胃癌发病的重要因素之一,其主要定植在胃上皮细胞,与多种胃部疾病相关,通过脂多糖、二磷酸腺苷庚糖或毒力因子诱导经典和替代核因子kappa B(NF-κB)信号通路。NF-κB是细胞内的重要转录因子,参与调控多种生理活动,通过调节炎性反应、细胞增殖、转移和侵袭、细胞凋亡等相关基因的表达影响胃癌的发生和发展。本文综述了NF-κB参与幽门螺杆菌诱导胃癌进程的相关机制并回顾了靶向NF-κB信号通路的天然产物,旨在为胃癌的发病机制和诊断治疗提供更多参考。

Gastric cancer(GC)is the fifth most prevalent tumour in the world,with 768793 deaths worldwide in 2020,accounting for 7.7%of total cancer deaths.China has high incidence of gastric cancer,with a low overall survival rate and poor treatment prognosis,which has a significant impact on people's health and national economic development.Infection with the human pathogen Helicobacter pylori(H.pylori)is one of the important factors leading to the development of gastric cancer.It colonizes in gastric epithelial cells and it is associated with a variety of gastric diseases.H.pylori induces the classical and alternative nuclear factor kappa B(NF-κB)signalling pathway through lipopolysaccharide,adenosine diphosphate heptose,or virulence factors.NF-κB is an important intracellular transcription factor,involved in the regulation of multiple physiological activities,and influences the development of gastric cancer by regulating the expression of genes related to inflammatory response,cell proliferation,metastasis and invasion,as well as apoptosis.Here,we summarized the mechanisms of NF-κB involved in Helicobacter pylori-induced gastric cancer and reviewed the natural products targeting the NF-κB signalling pathway,aiming to provide more references for the pathogenesis,diagnosis and treatment of gastric cancer.