嗜酸性粒细胞在肺癌中的研究进展

Research progress on eosinophils in lung cancer

嗜酸性粒细胞是人体中一种含有嗜酸性颗粒的细胞,主要在过敏性疾病(如哮喘、蠕虫感染等)中发挥关键作用。越来越多的研究证实嗜酸性粒细胞可以浸润多种肿瘤组织,并在特定情况下合成和分泌大量生物活性物质,如细胞毒性阳离子蛋白、细胞因子、生长因子、趋化因子、酶等,这些物质可能影响血管生成、基质重塑或改变肿瘤微环境,进而影响肿瘤发生发展。本文对嗜酸性粒细胞在肺癌中的研究新进展进行阐述。

Eosinophils are important immune cells that contain eosinophilic particles and play a key role in allergic diseases such as asthma and helminth infections.An increasing number of studies have confirmed that eosinophils infiltrate a variety of tumor tissues,which can synthesize and secrete a large number of bioactive substances under certain circumstances,such as cytotoxic cationic proteins,cytokines,growth factors,chemokines,enzymes and so on,which may affect angiogenesis and matrix remodeling or change the tumor microenvironment,thereby affecting tumor progression.This review focused on the role of eosinophils in lung cancer and provided an outlook on the issues in clinical and basic research.