高密度脂蛋白亚组分的临床意义及检测方法研究进展

Advances in clinical significance and detection methods research of high density lipoprotein subfractions

高密度脂蛋白(HDL)是临床心血管疾病的重要生物化学指标,高密度脂蛋白可逆向转运胆固醇,具有抗炎、抗氧化等功能,对心脑血管具有保护作用。新近一些研究证明心血管疾病患者的血浆HDL亚组分存在异常,被认为是评估心血管疾病的重要风险因子,其临床意义优于HDL总体异常,因此,HDL亚组分引起了越来越多的关注。本文对HDL亚组分的分离、检测方法及其与动脉粥样硬化和冠心病关系的研究进展进行阐述。

High density lipoprotein(HDL)is an important biochemical index of clinical cardiovascular disease.Many new studies have demonstrated abnormalities of plasma HDL subfractions in patients with this disease,and their clinical significance is greater than the overall abnormalities of HDL.Therefore,the HDL subfraction as an important factor in cardiovascular disease has attracted extensive research and attention.This article summarizes current research on HDL subfractions,their measurements and their relationships with atherosclerosis and coronary artery disease.