血脂异常女性绝经综合征的管理

Management of menopausal syndrome in women with dyslipidemia

绝经后女性由于脂质代谢失调和雌激素水平缺乏,血脂异常患病率升高。同时一些绝经后女性也会出现血管舒缩、躯体生理、精神心理及泌尿生殖道萎缩等绝经综合征。而绝经激素治疗是缓解绝经综合征最有效的措施;并且绝经早期启用MHT可降低心血管损害。但绝经激素治疗会带来血栓栓塞性疾病如静脉栓塞、心肌梗死和脑卒中的发生风险,且不同的用药方案对血脂代谢的影响也各不相同,针对不同类型血脂异常的绝经综合征女性应采取个性化的治疗方案。因此,本文对存在血脂异常的绝经综合征女性的管理与治疗进行阐述,为个性化管理绝经后血脂异常女性提供临床参考。

The prevalence of dyslipidemia is increased in postmenopausal women due to dysregulation of lipid metabolism and deficiency of estrogen levels.At the same time,some postmenopausal women also have menopausal syndromes such as vasomotor symptoms,physical physiology,mental psychology,and urogenital tract atrophy.Menopausal hormone therapy is the most effective measure to alleviate menopausal syndrome.And initiating MHT in early menopause can reduce cardiovascular damage.However,menopausal hormone therapy can also bring the risk of thromboembolic diseases such as venous embolism,myocardial infarction and stroke.Different drug regimens have different effects on lipid metabolism.Women with menopausal syndrome should take individualized treatment plans for different types of dyslipidemia.Therefore,this article reviews the management and treatment of menopausal syndrome in women with dyslipidemia,so as to provide a reference for personalized management of dyslipidemia in postmenopausal women.