阿魏酸哌嗪联合厄贝沙坦在糖尿病肾病中的应用效果及对肾功能的影响

Application Effect of Piperazine Ferulate Combined with Irbesartan in the Patients with Diabetic Nephropathy and Influence for Kidney Function

目的:探究阿魏酸哌嗪联合厄贝沙坦在糖尿病肾病中的疗效及对肾功能的影响。方法:将2019年6月—2022年2月景德镇市第二人民医院的82例糖尿病肾病患者根据随机数字表法分为对照组41例和观察组41例。对照组采用厄贝沙坦进行治疗,观察组则采用阿魏酸哌嗪联合厄贝沙坦进行治疗,以12周为一个比较期。比较两组治疗总有效率、治疗前后主肾动脉血流指标[收缩期最大流速(Vps)、舒张末期血流速度(Ved)及肾阻力指数(RI)]、肾功能指标[血肌酐(Cr)、24 h尿蛋白、血清尿素氮(BUN)、尿白蛋白排泄率(UAER)及肾小球滤过率(GFR)]。结果:观察组治疗总有效率为90.24%,显著高于对照组的65.85%,差异有统计学意义(P<0.05)。治疗前两组主肾动脉血流指标、肾功能指标比较,差异均无统计学意义(P>0.05)。治疗12周后两组主肾动脉Vps、Ved均较治疗前提高,观察组上述指标均显著高于对照组,两组RI均较治疗前降低,且观察组RI低于对照组;两组Cr、24h尿蛋白、BUN、UAER较治疗前均显著降低,且观察组均显著低于对照组,两组GFR均较治疗前升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。结论:阿魏酸哌嗪联合厄贝沙坦在糖尿病肾病中的疗效较好,且可有效改善肾功能,在糖尿病肾病患者中的应用价值相对较高。

Objective:To investigate the effect of Piperazine Ferulate combined with Irbesartan in the patients with diabetic nephropathy and influence for kidney function.Method:A total of 82 patients with diabetic nephropathy in the Second People's Hospital of Jingdezhen from June 2019 to February 2022 were divided into the control group with 41 cases and the observation group with 41 cases according to the random number table method.The control group were treated with Irbesartan,the observation group were treated with Piperazine Ferulate combined with Irbesartan.The total effective rates,main renal artery blood flow index[velocity peak systolic(Vps),velocity end diastolic(Ved),renal resistance index(RI)],renal function indexes[creatinine(Cr),24 h urine protein,blood urea nitrogen(BUN),urinary albumin excretion rate(UAER)and glomeruar filtration rate(GFR)]before and after treatment of two groups were compared.Result:The total effective rate of the observation group was 90.24%,which was significantly higher than 65.85%of the control group,the difference was statistically significant(P<0.05).There were no significant differences in main renal artery blood flow indexes and renal function indexes between the two groups before treatment(P>0.05);after 12 weeks of treatment,the Vps and Ved of the main renal artery in the two groups were higher than those before treatment,and the above indexes in the observation group were significantly higher than those in the control group,the RI in the two groups was lower than that before treatment,and the RI in the observation group was lower than that in the control group;the Cr,24 h urine protein,BUN and UAER of the two groups were significantly lower than those before treatment,and the observation group was significantly lower than the control group,the GFR of the two groups were higher than those before treatment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).Conclusion:The effect of Piperazine Ferulate combined with Irbesartan in the patients with diabetic nephropathy is better,and can effectively improve kidney function,so its application value in the patients with diabetic nephropathy is relatively higher.