桑枝总生物碱与阿卡波糖在痰浊瘀阻型餐后高血糖患者中的临床疗效比较

Comparison of Clinical Efficacy of Sangzhi Alkaloids and Acarbose in Patients with Postprandial Hyperglycemia Caused by Phlegm Turbidity and Blood Stasis Obstruction Syndrome

目的:比较桑枝总生物碱(SZ-A)和阿卡波糖(AC)在痰浊瘀阻型餐后高血糖患者中的临床效果及中医证候改善差异性。方法:将90例痰浊瘀阻型2型糖尿病患者。患者被随机分为对照组(接受AC治疗)和治疗组(接受SZ-A治疗),对照组30例,治疗组60例。研究期为12周,期间定期对患者进行随访,并观察药物的临床指标。结果:治疗后,治疗组的中医临床疗效为75%,显著优于对照组的40%。在血液指标方面,两组患者治疗后的血糖、胰岛素、胆固醇等指标均有明显改善。尤其在甘油三酯(TG)的改善程度上,SZ-A组明显优于AC组。此外,两组患者的体重指数(BMI)在治疗后都有所下降。结论:SZ-A和AC在降低痰浊瘀阻型餐后高血糖患者的血糖水平上具有同等效果,但SZ-A在改善中医证候积分、临床疗效、降低总胆固醇、炎症反应、以及减少胃肠道不良反应方面更优于AC。

Objective:To compare the clinical effects and differences in traditional Chinese medicine syndrome improvement of total alkaloids of mulberry branches(SZ-A)and acarbose(AC)in patients with postprandial hyperglycemia of phlegm turbidity and blood stasis type.Methods:90 cases of type 2 diabetes with turbid phlegm and blood stasis were studied.The patients were randomly divided into a control group(receiving AC treatment)and a treatment group(receiving SZ-A treatment),with 30 cases in the control group and 60 cases in the treatment group.The research period is 12 weeks,during which patients are regularly followed up and clinical indicators of the medication are observed.Result:After treatment,the clinical efficacy of traditional Chinese medicine in the treatment group was 75%,significantly better than the control group’s 40%.In terms of blood indicators,both groups of patients showed significant improvement in blood glucose,insulin,cholesterol and other indicators after treatment.Especially in terms of the improvement of triglycerides(TG),the SZ-A group was significantly better than the AC group.In addition,the body mass index(BMI)of both groups of patients decreased after treatment.Conclusion:SZ-A and AC have the same effect in reducing blood sugar levels in patients with postprandial hyperglycemia caused by phlegm stagnation.However,SZ-A is superior to AC in improving traditional Chinese medicine syndrome scores,clinical efficacy,reducing total cholesterol,inflammatory reactions,and reducing gastrointestinal adverse reactions.