基于西安城市自然人群的甘油三酯葡萄糖乘积指数与系统免疫炎症指数的关联研究

Study on the relationship between triglyceride glucose index and systemic immune-inflammation index based on natural population in Xi'an

目的探索甘油三酯葡萄糖乘积指数(TyG)与机体炎症之间的关系。方法数据来自2018-2019年建立的中国西北区域自然人群队列中西安城市人群队列基线调查,根据TG和FPG构建反映机体胰岛素抵抗(IR)的TyG及TyG-BMI,以中性粒细胞、淋巴细胞、血小板计数构建反映机体炎症的系统免疫炎症指数(SII),采用logistic回归模型探索TyG与SII之间的关系。结果共有11491名研究对象纳入分析,调整协变量后,TyG每增加1个单位,高SII的风险增加21%(OR=1.21,95%CI:1.12~1.30),TyG处于Q4组人群高SII的风险是Q1组的1.34倍(OR=1.34,95%CI:1.18~1.52)。敏感性分析和亚组分析进一步证实TyG与SII关联稳定。在BMI位于18.5~23.9 kg/m^(2)的人群中,TyG作为连续变量时每增加1个单位,高SII的风险增加31%(OR=1.31,95%CI:1.18~1.45),作为分类变量时Q4组高SII的风险是Q1组的1.52倍(OR=1.52,95%CI:1.27~1.83);在BMI位于24.0~27.9 kg/m^(2)的人群中,TyG作为连续变量时每增加1个单位,高SII的风险增加20%(OR=1.20,95%CI:1.07~1.35),作为分类变量时无统计学关联。结论IR水平升高与机体炎症的发展密切相关,BMI可能调节了两者之间的关系。在超重或肥胖前早期预防IR水平升高对于机体炎症的控制可能具有积极作用。

Objective To investigate the relationship between triglyceride glucose index(TyG)and body inflammation.Methods The data were obtained from a baseline survey in population in Xi'an in natural population cohort study in northwest China established in 2018-2019.Based on TG and FPG,TyG/TyG-BMI was constructed to reflect insulin resistance(IR)in the body,and systemic immune-inflammation index(SII)reflecting inflammation in the body was constructed using neutrophil,lymphocyte,and platelet counts.A logistic regression model was used to explore the relationship between the TyG and the SII.Results A total of 11491 subjects were included in the analysis.After adjusting for covariates,each unit increase in the TyG increased the risk of high SII by 21%(OR=1.21,95%CI:1.12-1.30).The risk of high SII in the group with the TyG in Q4 was 1.34 times higher than that in the group Q1(OR=1.34,95%CI:1.18-1.52).Both sensitivity analysis and subgroup analysis further confirmed the stability of the association between the TyG and the SII.In the population with a BMI ranging from 18.5 to 23.9 kg/m^(2),for every unit increase in the TyG as a continuous variable,the risk for high SII increased by 31%(OR=1.31,95%CI:1.18-1.45).As a categorical variable,the risk for high SII in the Q4 group was 1.52 times higher than that in the Q1 group(OR=1.52,95%CI:1.27-1.83).In a population with BMIs ranging from 24.0 to 27.9 kg/m^(2),for every unit increase in the TyG as a continuous variable,the risk for high SII increased by 20%(OR=1.20,95%CI:1.07-1.35),and there was no significant difference when it was a categorical variable.Conclusions The increase in IR is closely related to the development of inflammation in the body,and BMI may regulate their relationship.Early prevention of elevated IR levels before overweight or obesity may have a positive effect on the control of inflammation in the body.